IGHG1 and SWAP70

Number of citations of the paper that reports this interaction (PMID 10681448)
14

Data Source:
HPRD (in vitro)

		IGHG1	SWAP70
Gene Name		immunoglobulin heavy constant gamma 1 (G1m marker)	SWAP switching B-cell complex 70kDa subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Plasma Membrane Lamellipodium
	Molecular Function	Antigen Binding Protein Binding	DNA Binding Calcium Ion Binding ATP Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Isotype Switching
Pathways
Drugs
Diseases
GWAS		IgG levels ( 23225573)
Protein-Protein Interactions		7 interactors: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	5 interactors: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5
Entrez ID		3500	23075
HPRD ID		11755	10378
Ensembl ID			ENSG00000133789
Uniprot IDs			E7EMB1 Q9UH65
PDB IDs			2DN6
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Isotype Switching DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Mediated Immunity Adaptive Immune Response Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Immunoglobulin Production Defense Response Response To Stimulus Negative Regulation Of Protein Deubiquitination Leukocyte Activation Involved In Immune Response B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Positive Regulation Of Viral Entry Into Host Cell Innate Immune Response Regulation Of Immune Response Immunoglobulin Secretion Regulation Of Protein Deubiquitination Phagocytosis Fc Receptor Signaling Pathway DNA Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Immunoglobulin Secretion Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Cytokine Production Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Lymphocyte Activation Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Transcription Forebrain Morphogenesis Regulation Of Viral Release From Host Cell Lateral Ventricle Development Protein Destabilization Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Leukocyte Activation Regulation Of Cytokine Production Protein Trimerization
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