IGHG1 and FCGR3A

Number of citations of the paper that reports this interaction (PMID 15037082)
28

Data Source:
HPRD (in vitro)

		IGHG1	FCGR3A
Gene Name		immunoglobulin heavy constant gamma 1 (G1m marker)	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Protein Binding	IgG Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response
Pathways			Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		IgG levels ( 23225573)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25
Entrez ID		3500	2214
HPRD ID		11755	00903
Ensembl ID			ENSG00000203747
Uniprot IDs			E9PG94 M9MML0 P08637
PDB IDs			3AY4 3SGJ 3SGK
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Isotype Switching DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Mediated Immunity Adaptive Immune Response Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Immunoglobulin Production Defense Response Response To Stimulus Negative Regulation Of Protein Deubiquitination Leukocyte Activation Involved In Immune Response B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Positive Regulation Of Viral Entry Into Host Cell Innate Immune Response Regulation Of Immune Response Immunoglobulin Secretion Regulation Of Protein Deubiquitination Phagocytosis Fc Receptor Signaling Pathway DNA Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Immunoglobulin Secretion Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Cytokine Production Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Lymphocyte Activation Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Transcription Forebrain Morphogenesis Regulation Of Viral Release From Host Cell Lateral Ventricle Development Protein Destabilization Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Leukocyte Activation Regulation Of Cytokine Production Protein Trimerization	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis
Tagcloud ?			arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?			arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?