IGHG1 and FCGR3B

Number of citations of the paper that reports this interaction (PubMedID 10917521)
0

Data Source:
HPRD (in vitro)

		IGHG1	FCGR3B
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	Fc gamma receptor IIIb
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	IgG Receptor Activity IgG Binding GPI Anchor Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity	Antibody-dependent Cellular Cytotoxicity Immune Response Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway
Pathways			Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Muromonab Alemtuzumab Alefacept Natalizumab Palivizumab Daclizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Blood protein levels ( 30072576) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233 28067908) Limited cutaneous systemic scleroderma ( 29293537) Monocyte count ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7	2 interacting genes: APCS IGHG1
Entrez ID		3500	2215
HPRD ID		11755	09951
Ensembl ID		ENSG00000211896	ENSG00000162747
Uniprot IDs			A0A3B3ISU3 H0Y4U3 O75015
PDB IDs			1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?		Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization	Acute Inflammatory Response Blood Microparticle Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Negative Regulation Of Monocyte Differentiation Complement Component C1q Complex Binding Inflammatory Response Antibody-dependent Cellular Cytotoxicity IgG Immunoglobulin Complex Immunoglobulin Complex, Circulating Virion Binding Hypersensitivity Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Glycoprotein Metabolic Process Defense Response To Other Organism Host-mediated Suppression Of Viral Proces Defense Response To Symbiont Immunoglobulin Receptor Binding Acute Inflammatory Response To Antigenic Stimulus Regulation Of Monocyte Differentiation Immunoglobulin Complex Chaperone-mediated Protein Complex Assembly Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Antigen Binding Complement Activation, Classical Pathway Inflammatory Response To Antigenic Stimulus Acute-phase Response Immunoglobulin Mediated Immune Response Immune Response Defense Response Response To External Biotic Stimulus Negative Regulation Of Myeloid Leukocyte Differentiation Regulation Of Acute Inflammatory Response B Cell Receptor Signaling Pathway B Cell Mediated Immunity Complement Activation Extracellular Space Antibacterial Humoral Response Host-mediated Perturbation Of Viral Process Negative Regulation Of Wound Healing Negative Regulation Of Viral Process Regulation Of Immune System Process Leukocyte Mediated Cytotoxicity Negative Regulation Of Myeloid Cell Differentiation Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Host-mediated Perturbation Of Symbiont Process Unfolded Protein Binding
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