IGHG1 and FCGR3B

Number of citations of the paper that reports this interaction (PMID 10917521)
91

Data Source:
HPRD (in vitro)

		IGHG1	FCGR3B
Gene Name		immunoglobulin heavy constant gamma 1 (G1m marker)	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Protein Binding	IgG Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Immune Response
Pathways
Drugs			Cetuximab Etanercept Intravenous Immunoglobulin Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab
Diseases
GWAS		IgG levels ( 23225573)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	2 interactors: APCS IGHG1
Entrez ID		3500	2215
HPRD ID		11755	09951
Ensembl ID			ENSG00000162747
Uniprot IDs			M9MML6 O75015
PDB IDs			1E4J 1E4K 1FNL 1T83 1T89
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Isotype Switching DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Mediated Immunity Adaptive Immune Response Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Immunoglobulin Production Defense Response Response To Stimulus Negative Regulation Of Protein Deubiquitination Leukocyte Activation Involved In Immune Response B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Positive Regulation Of Viral Entry Into Host Cell Innate Immune Response Regulation Of Immune Response Immunoglobulin Secretion Regulation Of Protein Deubiquitination Phagocytosis Fc Receptor Signaling Pathway DNA Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Immunoglobulin Secretion Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Cytokine Production Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Lymphocyte Activation Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Transcription Forebrain Morphogenesis Regulation Of Viral Release From Host Cell Lateral Ventricle Development Protein Destabilization Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Leukocyte Activation Regulation Of Cytokine Production Protein Trimerization	Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Monocyte Differentiation Negative Regulation Of Glycoprotein Metabolic Process Chaperone-mediated Protein Complex Assembly Regulation Of Monocyte Differentiation Negative Regulation Of Acute Inflammatory Response Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Interaction With Symbiont Immune Response Regulation Of Immune System Process Defense Response Acute-phase Response Negative Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Negative Regulation Of Viral Process Acute Inflammatory Response Negative Regulation Of Myeloid Cell Differentiation Immune System Process Negative Regulation Of Inflammatory Response Regulation Of Myeloid Leukocyte Differentiation Complement Activation, Classical Pathway Regulation Of Wound Healing Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Viral Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Protein Activation Cascade Regulation Of Myeloid Cell Differentiation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Locomotion Response To Stress Phagocytosis Leukocyte Mediated Immunity Fc Receptor Signaling Pathway Adaptive Immune Response Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Folding Cellular Protein Complex Assembly
Tagcloud ?			advantages applicability carry cloned cnas cnvs comparable competitive competitors copy cost erbb2 invaluable issues limitations mrcpcr nci numbers panel paralog prt reproducibility requirement responsiveness shorter solve utilizing variations
Tagcloud (Difference) ?			advantages applicability carry cloned cnas cnvs comparable competitive competitors copy cost erbb2 invaluable issues limitations mrcpcr nci numbers panel paralog prt reproducibility requirement responsiveness shorter solve utilizing variations
Tagcloud (Intersection) ?