ALB and FNDC3B

Number of citations of the paper that reports this interaction (PubMedID 36811957)
49

Data Source:
BioGRID (unspecified method)

		ALB	FNDC3B
Description		albumin	fibronectin type III domain containing 3B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Platelet Alpha Granule Lumen Protein-containing Complex Extracellular Exosome Blood Microparticle	Cytoplasm Endomembrane System Membrane
	Molecular Function	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Lipid Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Pyridoxal Phosphate Binding Identical Protein Binding Metal Ion Binding Protein-folding Chaperone Binding Exogenous Protein Binding Enterobactin Binding	RNA Binding Protein Binding
	Biological Process	Cellular Response To Starvation Response To Nutrient Levels Negative Regulation Of Mitochondrial Depolarization Cellular Response To Calcium Ion Starvation Cellular Oxidant Detoxification
Pathways		Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation HDL remodeling Cytoprotection by HMOX1 Aspirin ADME Prednisone ADME Ciprofloxacin ADME
Drugs		Amsacrine Cefotaxime Phenol Norelgestromin Aniline Guaiacol Artenimol Silver Patent Blue
Diseases
GWAS		Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Esterified cholesterol levels ( 29084231) Free cholesterol levels ( 29084231) Free cholesterol levels in large LDL ( 29084231) Large LDL particle concentration ( 29084231) Lipid metabolism phenotypes ( 22286219) Medium LDL particle concentration ( 29084231) Prostate cancer ( 23535732) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231)	Appendicular lean mass ( 33097823) Bell's palsy ( 33602968) Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal hysteresis ( 30894546) Corneal resistance factor ( 30894546 31246245) Corneal structure ( 23291589) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 31562340 33713608 23563607 28552196 25282103 25429064) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 25173106 31798171 28073927 29785010 30054594 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: AGA AMBP APOE CRYAA CUBN F7 FCGRT FNDC3B FOXP1 HNF1A IMMT KLK3 LAMTOR5 LINC00624 LINC02582 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RNF181 RYR2 SRGN ST13 TK1 USP7 VWF WEE2-AS1 YWHAG	124 interacting genes: ABHD11 ABHD8 ACTG1 ACTMAP ADGRF5 AHNAK ALB ANXA2 ATP1A1 ATP5F1A BBS2 BICRAL BRWD1 C10orf55 C22orf15 CAMK2D CAP1 CAPN3 CDC42 CEMP1 CFL1 DAPL1 DSTN DUSP10 EEF1E1 EGFR EIF5A2 ENO1 ERCC6 ERH ERI3 FUS GAS2L3 GOLT1B GTF2F1 HAPLN2 HNRNPD HNRNPK HSP90AB4P HSPA1A HSPA5 HSPA7 HSPA8 HSPB1 HSPD1 HSPH1 KARS1 KLHDC7B KRTAP11-1 L3MBTL3 LARP4 MBD3L1 MBOAT7 MCCD1 MVP MYH14 MYL6 NAGK NCAM2 NCK1 NDUFAB1 P4HB PARP1 PC PGK1 PIK3R4 PKLR POGZ POU6F2 PPP6R2 PRKAA2 PSMA3 PTMA RAB1A RAB1B RAN REL RPL12 RPL15 RPL17 RPL23 RPL28 RPL34 RPS14 RPS3 RPS3A RPS6 RUSC1 SNRPD3 SOD1 SPCS2 SPMIP10 SPMIP5 SPSB2 SRARP STPG4 SUGT1 SUOX SYNCRIP TEKT5 TEPSIN TESMIN TEX48 TGM2 TIAM1 TKT TOX4 TPM3 TRAF2 TRIM16 TRIM35 TRIM42 TRIP13 TTN TUBB4A TUBGCP6 TXN UBA52 UBAP2 USP54 VAC14 YPEL3 YWHAZ ZMYND19
Entrez ID		213	64778
HPRD ID		00062	10943
Ensembl ID		ENSG00000163631	ENSG00000075420
Uniprot IDs		P02768	Q53EP0
PDB IDs		1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2N0X 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4BKE 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4K71 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9 4N0F 4N0U 4S1Y 4Z69 5FUO 5GIX 5GIY 5ID7 5IFO 5IJF 5UJB 5VNW 5X52 5YB1 5YOQ 5Z0B 6A7P 6EZQ 6JE7 6L4K 6M4R 6M58 6M5D 6M5E 6QIO 6QIP 6R7S 6WUW 6XV0 6YG9 6ZL1 7A9C 7AAE 7AAI 7D6J 7DJN 7DL4 7EEK 7FFR 7FFS 7JWN 7QFE 7VR0 7VR9 7WKZ 7WLF 7WOJ 7WOK 7WZ9 7X7X 7Y2D 7Z57 8A9Q 8CKS 8EW4 8EW7 8EY5 8H0O 8ISM 8ITR 8ITT 8J8E 8K1Y 8OI2 8Q3F 8RCO 8RCP 8RGK 8RGL 8VAC 8VAE 8VAF 8Y9S 8Y9T 8Y9U 8YG7 8YXA 8YXB 8Z8V 9CSG
Enriched GO Terms of Interacting Partners?		Steroid Metabolic Process Protein-containing Complex Vascular Endothelial Growth Factor Binding Extracellular Space Blood Microparticle Negative Regulation Of Multicellular Organismal Process Vascular Endothelial Growth Factor Receptor Activity Genitalia Development Vitamin Transport Cobalamin Transport Vagina Development Alcohol Metabolic Process Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of TOR Signaling Response To Reactive Oxygen Species Platelet Alpha Granule Lumen TORC1 Signaling Negative Regulation Of Amyloid Fibril Formation Regulation Of Blood Coagulation Regulation Of Hemostasis Extracellular Region Regulation Of Defense Response To Bacterium Female Genitalia Development Vitamin Transmembrane Transport Regulation Of Amyloid Fibril Formation Negative Regulation Of Platelet Activation Transcytosis Receptor Complex Vascular Endothelial Growth Factor Signaling Pathway TOR Signaling U1 SnRNP Positive Regulation Of TOR Signaling Cytochrome C Metabolic Process Antioxidant Activity Extracellular Matrix Extracellular Exosome Negative Regulation Of Phospholipid Efflux Sterol Metabolic Process Chemical Homeostasis Negative Regulation Of Gene Expression High-density Lipoprotein Particle Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Cholesterol Metabolic Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Positive Regulation Of Multicellular Organismal Process Calcium Ion Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway	Extracellular Exosome Cytosol Cytoplasm Cytoplasmic Translation Cytosolic Ribosome Focal Adhesion Ribonucleoprotein Complex RNA Binding ATP-dependent Protein Folding Chaperone Translation Structural Constituent Of Ribosome Ribosome Protein Refolding Cadherin Binding Cytosolic Large Ribosomal Subunit Protein-containing Complex Melanosome Protein Binding Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding ATP Metabolic Process Protein Metabolic Process Protein Phosphatase Binding Cytosolic Small Ribosomal Subunit Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Nucleotide Binding Response To Nitric Oxide Protein Folding Positive Regulation Of Protein Metabolic Process Organophosphate Metabolic Process Enzyme Binding Actin Filament-based Process Macromolecule Metabolic Process Nucleotide Metabolic Process Nucleus Vesicle Structural Molecule Activity Conferring Elasticity Purine Nucleotide Metabolic Process Protein Folding Chaperone Nucleobase-containing Small Molecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway ATP Binding Positive Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Unfolded Protein Binding Nucleoside Phosphate Metabolic Process Cellular Response To Nitric Oxide
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