THRAP3 and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		THRAP3	SHANK3
Description		thyroid hormone receptor associated protein 3	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex Nuclear Speck Exon-exon Junction Complex Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding ATP Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Phosphoprotein Binding	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing Circadian Rhythm RNA Splicing Positive Regulation Of Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Rhythmic Process	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Neurexins and neuroligins Neurexins and neuroligins RET signaling
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		13 interacting genes: APBB1 CEBPA CLK1 CSNK2A1 NEDD4 OGT PIN1 RNF10 SHANK3 SREK1 USP7 WEE2-AS1 YWHAG	152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2
Entrez ID		9967	85358
HPRD ID		07543	18979
Ensembl ID		ENSG00000054118	ENSG00000251322
Uniprot IDs		Q9Y2W1	Q9BYB0
PDB IDs			6CPK 7C7I 7C7J
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Protein Localization To Vacuole Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Phosphothreonine Residue Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphoserine Residue Binding Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Lysosome TORC1 Signaling Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Translational Initiation Proline-rich Region Binding Signal Transduction Sin3-type Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Metabolic Process Regulation Of TOR Signaling Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization Response To Nutrient Levels Regulation Of Primary Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Catabolic Process	Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization
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