NAT10 and CD2BP2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		NAT10	CD2BP2
Description		N-acetyltransferase 10	CD2 cytoplasmic tail binding protein 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane Midbody Small-subunit Processome	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Protein Binding ATP Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups TRNA Cytidine N4-acetyltransferase Activity DNA Polymerase Binding MRNA N-acetyltransferase Activity 18S RRNA Cytidine N-acetyltransferase Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	RRNA Modification TRNA Wobble Cytosine Modification RRNA Processing Regulation Of Translation Protein Acetylation TRNA Processing RNA Modification Regulation Of Centrosome Duplication RRNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Translation TRNA Acetylation RRNA Acetylation Involved In Maturation Of SSU-rRNA	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing
Pathways		rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CD2BP2 CENATAC MDM2 PARP1 SREK1 SUMO2 TP53 UBC UBE2D2 UBE2I USP7	22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		55226	10421
HPRD ID		10964	05127
Ensembl ID		ENSG00000135372	ENSG00000169217
Uniprot IDs		Q9H0A0	A0A024QZC1 O95400
PDB IDs		6VLA 7MQ8 7MQ9	1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification SUMO Transferase Activity PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Cellular Response To Actinomycin D Protein Modification By Small Protein Conjugation Nuclear Body Response To Actinomycin D Nucleoplasm Cellular Response To UV-C Response To Gamma Radiation Protein Sumoylation Mitochondrial DNA Repair P53 Binding Protein Modification Process Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Telomere Maintenance Proteolysis Response To UV-C Protein Tag Activity Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Response To Ionizing Radiation Negative Regulation Of Proteolysis Response To UV Disordered Domain Specific Binding Cellular Response To Gamma Radiation Presynaptic Cytosol Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Radiation Postsynaptic Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of Programmed Necrotic Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly
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