DDX3X and WBP4

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		DDX3X	WBP4
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	WW domain binding protein 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Nuclear Speck Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Nucleoplasm Spliceosomal Complex Plasma Membrane Nuclear Speck
	Molecular Function	DNA Binding RNA Binding GTPase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding ATPase Activity Nucleoside-triphosphatase Activity Translation Initiation Factor Binding RNA Stem-loop Binding Ribosomal Small Subunit Binding CTPase Activity Poly(A) RNA Binding MRNA 5'-UTR Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Transcription, DNA-templated Chromosome Segregation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein Complex Assembly DNA Duplex Unwinding Positive Regulation Of Interferon-beta Production Stress Granule Assembly Intracellular Signal Transduction Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	MRNA Cis Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 23266558)
Protein-Protein Interactions		12 interactors: APBB1 CSNK2A1 IL7R NEDD4 NFKB2 NUP62 PIN1 SREK1 WBP4 XPO1 YWHAQ ZNF512B	44 interactors: BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DIAPH1 DNM2 EFTUD2 EWSR1 FUS HLTF HNRNPK HNRNPU HTATSF1 KHDRBS1 NONO PABPC1 PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B3 SF3B4 SFPQ SNRNP70 SNRPA SNRPB TCERG1 WAS WBP11 WIPF1 XRCC6 ZNF207
Entrez ID		1654	11193
HPRD ID		02154	16086
Ensembl ID		ENSG00000215301	ENSG00000120688
Uniprot IDs		O00571	B7Z4M2 O75554
PDB IDs		2I4I 2JGN 3JRV	2DK1 2JXW
Enriched GO Terms of Interacting Partners?		Response To Cytokine Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cytokine-mediated Signaling Pathway Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Cellular Component Organization Signaling Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Cycle Regulation Of Protein Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Thymidylate Synthase Biosynthetic Process Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Follicular Dendritic Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Cell Death Death Cellular Response To Organic Substance Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Process MRNA Transport Regulation Of Mitotic Nuclear Division Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly MRNA 3'-splice Site Recognition Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Cellular Component Assembly MRNA Splice Site Selection Cellular Process Metabolic Process MRNA 3'-end Processing Transcription, DNA-templated RNA Biosynthetic Process RNA 3'-end Processing Spliceosomal SnRNP Assembly Posttranscriptional Regulation Of Gene Expression Attachment Of Spindle Microtubules To Kinetochore Rhythmic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Translational Initiation Macromolecule Biosynthetic Process Positive Regulation Of Translation Actin Polymerization Or Depolymerization Negative Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Positive Regulation Of Gene Expression MRNA Polyadenylation Cellular Response To Osmotic Stress
Tagcloud ?		aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically
Tagcloud (Difference) ?		aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically
Tagcloud (Intersection) ?