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DDX3X and CRYAA
Number of citations of the paper that reports this interaction (PubMedID
24453475
)
30
Data Source:
BioGRID
(pull down)
DDX3X
CRYAA
Description
DEAD-box helicase 3 X-linked
crystallin alpha A
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Cytoskeleton
Plasma Membrane
Cytoplasmic Stress Granule
Membrane
Cytosolic Small Ribosomal Subunit
Lamellipodium
Cell Leading Edge
Secretory Granule Lumen
Cell Projection
P Granule
Canonical Inflammasome Complex
Extracellular Exosome
NLRP3 Inflammasome Complex
Ficolin-1-rich Granule Lumen
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
RNA Binding
RNA Helicase Activity
MRNA Binding
GTPase Activity
Helicase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Poly(A) Binding
Eukaryotic Initiation Factor 4E Binding
Hydrolase Activity
ATP Hydrolysis Activity
Ribonucleoside Triphosphate Phosphatase Activity
Translation Initiation Factor Binding
RNA Strand Annealing Activity
Signaling Adaptor Activity
RNA Stem-loop Binding
Gamma-tubulin Binding
Ribosomal Small Subunit Binding
CTPase Activity
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
MRNA 5'-UTR Binding
Structural Molecule Activity
Structural Constituent Of Eye Lens
Protein Binding
Identical Protein Binding
Metal Ion Binding
Unfolded Protein Binding
Biological Process
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Translational Initiation
Regulation Of Translation
Apoptotic Process
Chromosome Segregation
Gamete Generation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Virus
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Negative Regulation Of Translation
Cell Differentiation
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Stress Granule Assembly
Positive Regulation Of Toll-like Receptor 7 Signaling Pathway
Positive Regulation Of Toll-like Receptor 8 Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Ribosome Biogenesis
Cytosolic Ribosome Assembly
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation
Lipid Homeostasis
Positive Regulation Of Mitochondrial Translation
Cellular Response To Arsenic-containing Substance
Cellular Response To Osmotic Stress
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Canonical Wnt Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein K63-linked Ubiquitination
Protein Localization To Cytoplasmic Stress Granule
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Response To Hypoxia
Lens Development In Camera-type Eye
Lens Morphogenesis In Camera-type Eye
Apoptotic Process
Mitochondrion Organization
Actin Filament Organization
Microtubule-based Process
Tubulin Complex Assembly
Visual Perception
Response To Heat
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Growth
Negative Regulation Of Intracellular Transport
Protein Refolding
Response To Hydrogen Peroxide
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Embryonic Camera-type Eye Morphogenesis
Protein Stabilization
Apoptotic Process Involved In Morphogenesis
Response To UV-A
Lens Fiber Cell Morphogenesis
Pathways
Neutrophil degranulation
Drugs
Diseases
GWAS
Refractive error (
32231278
)
Age-related nuclear cataracts (
24951543
33311586
)
Diastolic blood pressure (
27618452
27841878
28135244
28739976
)
Metabolite levels (
23823483
)
Systolic blood pressure (
27618452
27841878
28739976
)
Interacting Genes
101 interacting genes:
ANXA1
APBB1
CEBPA
CRYAA
CSNK2A1
DSCR9
DUX4
ESR1
HNF4A
IKBKE
IL7R
LINC01232
LINC01554
MAVS
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NEDD4
NFKB2
NUP62
OGT
PIN1
SREK1
SRPK2
SUMO2
TRIM25
USP7
USP9X
WBP4
XPO1
YWHAQ
ZNF512B
134 interacting genes:
-
ADPRHL1
AKT3
ALB
ALDH1L2
ANKRD44
APPL2
ARFGAP1
ARMCX4
ARRDC1-AS1
ATG16L1
BCL2L1
BORA
BTRC
CAMKK2
CD209
CDC40
CEBPZ
CENPH
CER1
CNOT8
COPB2
CRTAC1
CRYAB
CRYBA1
CRYBB2
CRYGC
CRYGD
CRYZ
CS
CSTF2T
DCAF11
DCAF8
DCK
DDX3X
DUS4L
E2F7
EEPD1
ETFB
EYA4
FAM131B
FAM131C
FAM182A
FASN
GIGYF2
GLYATL1
GNAI2
GORASP2
GSTZ1
HABP4
HCLS1
HSPB1
HSPB2
IGHG1
IGKV1-5
JKAMP
KBTBD12
KIZ
KNG1
LALBA
LARP6
LIMA1
MAP3K7CL
MAPKBP1
MCM7
MCRS1
MINDY1
MIP
MPHOSPH6
MTERF4
MYO5C
NAT9
NCF4
NTAQ1
NUP43
OSBPL3
OTOGL
OTULIN
PABIR2
PAFAH1B1
PCYT2
PHC1
PLAUR
PMS2
PRM2
PSMB6
PTPN2
PTTG2
QRICH1
RAB24
RAB29
RAB3C
RAB40B
RAB43
RAD51
RBBP7
RNASEH1
RNGTT
RPS6KA5
SDCBP
SEC24C
SEH1L
SESN2
SGCD
SLC20A1
SLC25A25
SLC25A26
SLC25A28
SPG21
SSBP4
SULF1
SYK
TASL
TEAD4
TFDP1
TGOLN2
TLE4
TMEM254
TMEM52B
TSR3
TTC27
TTC39B
TUBAL3
TUBGCP5
UBR2
UPP1
WDR55
WDR83
WIPI2
WWC2
ZIM2
ZNF3
ZNF639
ZSCAN20
Entrez ID
1654
1409
HPRD ID
02154
00427
Ensembl ID
ENSG00000215301
ENSG00000160202
Uniprot IDs
A0A2R8YDT5
A0A2R8YFS5
O00571
A0A8C8KJZ9
P02489
PDB IDs
2I4I
2JGN
3JRV
4O2C
4O2E
4O2F
4PX9
4PXA
5E7I
5E7J
5E7M
6CZ5
6O5F
7LIU
8SSW
6T1R
Enriched GO Terms of Interacting Partners
?
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Gene Expression
Extracellular Vesicle
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Translation
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cell Motility
Negative Regulation Of Locomotion
Negative Regulation Of Cell Migration
Negative Regulation Of Cytokine Production
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of MRNA Metabolic Process
Regulation Of Angiogenesis
Regulation Of Vasculature Development
Regulation Of Translation
Negative Regulation Of Protein Metabolic Process
Regulation Of MRNA Stability
Regulation Of RNA Stability
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Multicellular Organismal Process
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Signaling
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Communication
Regulation Of MRNA Metabolic Process
Structural Constituent Of Eye Lens
Lens Development In Camera-type Eye
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