COMP and FN1

Number of citations of the paper that reports this interaction (PMID 12225811)
20

Data Source:
HPRD (in vitro)

		COMP	FN1
Gene Name		cartilage oligomeric matrix protein	fibronectin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Skeletal System Development Growth Plate Cartilage Development Apoptotic Process Cell Adhesion Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of Apoptotic Process Limb Development	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration
Pathways		ECM proteoglycans Integrin cell surface interactions	Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Calcium	Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COL2A1 COL9A1 FN1 OTX1	96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL
Entrez ID		1311	2335
HPRD ID		02632	00626
Ensembl ID		ENSG00000105664	ENSG00000115414
Uniprot IDs		B4DKJ3 P49747	P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6
PDB IDs		3FBY	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Embryonic Morphogenesis Multicellular Organismal Metabolic Process Nervous System Development Inner Ear Morphogenesis Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Bone Morphogenesis Ear Morphogenesis Organ Morphogenesis Tissue Homeostasis Cell Morphogenesis Inner Ear Development Cartilage Development Embryo Development Bone Development Locomotion Ear Development Multicellular Organismal Homeostasis Calcium-independent Cell-matrix Adhesion Connective Tissue Development Skeletal System Morphogenesis Movement Of Cell Or Subcellular Component System Development Diencephalon Morphogenesis Embryonic Organ Morphogenesis Generation Of Neurons Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Multicellular Organismal Development Cell Development Anatomical Structure Development Integrin Activation Embryonic Organ Development Otic Vesicle Development Axonogenesis Developmental Process Growth Plate Cartilage Development Skeletal System Development Embryonic Skeletal Joint Morphogenesis Axon Development	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis
Tagcloud ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Difference) ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Intersection) ?