COMP and COL2A1

Number of citations of the paper that reports this interaction (PMID 9685393)
60

Data Source:
HPRD (in vitro)

		COMP	COL2A1
Gene Name		cartilage oligomeric matrix protein	collagen, type II, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Growth Plate Cartilage Development Apoptotic Process Cell Adhesion Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of Apoptotic Process Limb Development	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		ECM proteoglycans Integrin cell surface interactions	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs		Calcium
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COL2A1 COL9A1 FN1 OTX1	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		1311	1280
HPRD ID		02632	00361
Ensembl ID		ENSG00000105664	ENSG00000139219
Uniprot IDs		B4DKJ3 P49747	P02458
PDB IDs		3FBY	1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Embryonic Morphogenesis Multicellular Organismal Metabolic Process Nervous System Development Inner Ear Morphogenesis Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Bone Morphogenesis Ear Morphogenesis Organ Morphogenesis Tissue Homeostasis Cell Morphogenesis Inner Ear Development Cartilage Development Embryo Development Bone Development Locomotion Ear Development Multicellular Organismal Homeostasis Calcium-independent Cell-matrix Adhesion Connective Tissue Development Skeletal System Morphogenesis Movement Of Cell Or Subcellular Component System Development Diencephalon Morphogenesis Embryonic Organ Morphogenesis Generation Of Neurons Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Multicellular Organismal Development Cell Development Anatomical Structure Development Integrin Activation Embryonic Organ Development Otic Vesicle Development Axonogenesis Developmental Process Growth Plate Cartilage Development Skeletal System Development Embryonic Skeletal Joint Morphogenesis Axon Development	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?