COMP

Description		cartilage oligomeric matrix protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Skeletal System Development Ossification Chondrocyte Development Endochondral Bone Growth Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Cell Adhesion Blood Coagulation Protein Secretion Animal Organ Morphogenesis Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Cartilage Development Protein Homooligomerization Muscle Cell Development Limb Development Bone Morphogenesis Platelet Aggregation Cellular Senescence Vascular Associated Smooth Muscle Cell Development Bone Growth Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation Cartilage Homeostasis
Pathways		Integrin cell surface interactions ECM proteoglycans
Drugs		Calcium
Diseases		Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB
Entrez ID		1311
HPRD ID		02632
Ensembl ID		ENSG00000105664
Uniprot IDs		P49747
PDB IDs		3FBY
Enriched GO Terms of Interacting Partners?		Epithelium Development Proteoglycan Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Tissue Development Positive Regulation Of Fibroblast Proliferation Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Metallochaperone Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Inner Ear Morphogenesis Endoplasmic Reticulum Lumen Biological Process Involved In Interaction With Symbiont Diencephalon Morphogenesis Wound Healing Collagen Trimer Metanephric Glomerulus Vasculature Development Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Regulation Of Fibroblast Proliferation Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Corticotropin Secretion Copper-dependent Protein Binding Copper Ion Export Collagen Type II Trimer Roof Of Mouth Development Extracellular Matrix Basement Membrane Collagen Type IX Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Metencephalon Development TRC Complex Identical Protein Binding Extracellular Matrix Structural Constituent Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport Lipid Digestion Copper Chaperone Activity Calcium-independent Cell-matrix Adhesion Nitric Oxide Transport Carbon Dioxide Transmembrane Transporter Activity Water Transmembrane Transporter Activity Animal Organ Morphogenesis Ameboidal-type Cell Migration Transepithelial Water Transport Carbon Dioxide Transmembrane Transport
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