COMP and COL9A1

Number of citations of the paper that reports this interaction (PMID 15047691)
12

Data Source:
HPRD (in vitro)

		COMP	COL9A1
Gene Name		cartilage oligomeric matrix protein	collagen, type IX, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type IX Trimer Endoplasmic Reticulum Lumen
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding
	Biological Process	Skeletal System Development Growth Plate Cartilage Development Apoptotic Process Cell Adhesion Organ Morphogenesis Extracellular Matrix Organization Negative Regulation Of Apoptotic Process Limb Development	Tissue Homeostasis Growth Plate Cartilage Development Axon Guidance Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		ECM proteoglycans Integrin cell surface interactions	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs		Calcium
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COL2A1 COL9A1 FN1 OTX1	3 interactors: COL2A1 COMP MAG
Entrez ID		1311	1297
HPRD ID		02632	00367
Ensembl ID		ENSG00000105664	ENSG00000112280
Uniprot IDs		B4DKJ3 P49747	B3KWS8 P20849
PDB IDs		3FBY	2UUR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Embryonic Morphogenesis Multicellular Organismal Metabolic Process Nervous System Development Inner Ear Morphogenesis Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Bone Morphogenesis Ear Morphogenesis Organ Morphogenesis Tissue Homeostasis Cell Morphogenesis Inner Ear Development Cartilage Development Embryo Development Bone Development Locomotion Ear Development Multicellular Organismal Homeostasis Calcium-independent Cell-matrix Adhesion Connective Tissue Development Skeletal System Morphogenesis Movement Of Cell Or Subcellular Component System Development Diencephalon Morphogenesis Embryonic Organ Morphogenesis Generation Of Neurons Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Multicellular Organismal Development Cell Development Anatomical Structure Development Integrin Activation Embryonic Organ Development Otic Vesicle Development Axonogenesis Developmental Process Growth Plate Cartilage Development Skeletal System Development Embryonic Skeletal Joint Morphogenesis Axon Development	Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Bone Morphogenesis Bone Morphogenesis Cartilage Development Limb Development Bone Development Connective Tissue Development Skeletal System Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Limb Bud Formation Skeletal System Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Otic Vesicle Development Organ Development Growth Plate Cartilage Development Embryonic Skeletal Joint Morphogenesis Embryonic Skeletal Joint Development Notochord Development Cartilage Condensation Cellular Response To BMP Stimulus Endochondral Bone Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Substantia Nigra Development Central Nervous System Development Negative Regulation Of Cell Death Organ Morphogenesis Endochondral Ossification System Development Neural Nucleus Development Cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Collagen Fibril Organization Negative Regulation Of Axonogenesis Collagen Catabolic Process Locomotion Multicellular Organismal Development Anatomical Structure Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chondrocyte Differentiation Midbrain Development Regulation Of Apoptotic Process Multicellular Organismal Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Regulation Of Cell Death
Tagcloud ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	ablation aggrecan betaig cartilage chondrocyte collagen comp compensatory disturbed endochondral epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii
Tagcloud (Difference) ?		20e ab11 acari amblyomma basepair ecdysone ecdysteroid ecdysteroids ecr ecre ecres endocrinol hebraeum heterodimerized hsp27 ixodid ixodidae kaufman koch mak mcblain mur palindrome pon ponasterone salivary supershifted tick usp	ablation aggrecan betaig cartilage chondrocyte collagen compensatory disturbed endochondral epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii
Tagcloud (Intersection) ?		comp