COMP and ATOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COMP	ATOX1
Description		cartilage oligomeric matrix protein	antioxidant 1 copper chaperone
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Extracellular Exosome	Cytosol
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding
	Biological Process	Skeletal System Development Ossification Chondrocyte Development Endochondral Bone Growth Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Cell Adhesion Blood Coagulation Protein Secretion Animal Organ Morphogenesis Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Cartilage Development Protein Homooligomerization Muscle Cell Development Limb Development Bone Morphogenesis Platelet Aggregation Cellular Senescence Vascular Associated Smooth Muscle Cell Development Bone Growth Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation Cartilage Homeostasis	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		Integrin cell surface interactions ECM proteoglycans	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		Calcium	Cisplatin Sucrose Benzamidine
Diseases		Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		1311	475
HPRD ID		02632	03779
Ensembl ID		ENSG00000105664	ENSG00000177556
Uniprot IDs		P49747	O00244
PDB IDs		3FBY	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3
Enriched GO Terms of Interacting Partners?		Epithelium Development Proteoglycan Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Tissue Development Positive Regulation Of Fibroblast Proliferation Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Metallochaperone Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Inner Ear Morphogenesis Endoplasmic Reticulum Lumen Biological Process Involved In Interaction With Symbiont Diencephalon Morphogenesis Wound Healing Collagen Trimer Metanephric Glomerulus Vasculature Development Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Regulation Of Fibroblast Proliferation Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Corticotropin Secretion Copper-dependent Protein Binding Copper Ion Export Collagen Type II Trimer Roof Of Mouth Development Extracellular Matrix Basement Membrane Collagen Type IX Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Metencephalon Development TRC Complex Identical Protein Binding Extracellular Matrix Structural Constituent Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport Lipid Digestion Copper Chaperone Activity Calcium-independent Cell-matrix Adhesion Nitric Oxide Transport Carbon Dioxide Transmembrane Transporter Activity Water Transmembrane Transporter Activity Animal Organ Morphogenesis Ameboidal-type Cell Migration Transepithelial Water Transport Carbon Dioxide Transmembrane Transport	Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting
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