COMP and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COMP	SGTB
Description		cartilage oligomeric matrix protein	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Extracellular Exosome	Membrane TRC Complex
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Skeletal System Development Ossification Chondrocyte Development Endochondral Bone Growth Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Cell Adhesion Blood Coagulation Protein Secretion Animal Organ Morphogenesis Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Cartilage Development Protein Homooligomerization Muscle Cell Development Limb Development Bone Morphogenesis Platelet Aggregation Cellular Senescence Vascular Associated Smooth Muscle Cell Development Bone Growth Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation Cartilage Homeostasis	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Integrin cell surface interactions ECM proteoglycans
Drugs		Calcium
Diseases		Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		1311	54557
HPRD ID		02632	18049
Ensembl ID		ENSG00000105664	ENSG00000197860
Uniprot IDs		P49747	Q96EQ0
PDB IDs		3FBY
Enriched GO Terms of Interacting Partners?		Epithelium Development Proteoglycan Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Tissue Development Positive Regulation Of Fibroblast Proliferation Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Metallochaperone Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Inner Ear Morphogenesis Endoplasmic Reticulum Lumen Biological Process Involved In Interaction With Symbiont Diencephalon Morphogenesis Wound Healing Collagen Trimer Metanephric Glomerulus Vasculature Development Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Regulation Of Fibroblast Proliferation Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Corticotropin Secretion Copper-dependent Protein Binding Copper Ion Export Collagen Type II Trimer Roof Of Mouth Development Extracellular Matrix Basement Membrane Collagen Type IX Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Metencephalon Development TRC Complex Identical Protein Binding Extracellular Matrix Structural Constituent Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport Lipid Digestion Copper Chaperone Activity Calcium-independent Cell-matrix Adhesion Nitric Oxide Transport Carbon Dioxide Transmembrane Transporter Activity Water Transmembrane Transporter Activity Animal Organ Morphogenesis Ameboidal-type Cell Migration Transepithelial Water Transport Carbon Dioxide Transmembrane Transport	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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