COL4A1 and SMAD1

  • Number of citations: 0 (PubMedID 14732718)
  • Data Source: HPRD (in vivo, two hybrid)

COL4A1

SMAD1

Name collagen type IV alpha 1 chain SMAD family member 1
Structure PDB 1LI1 PDB 1KHU
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Diseases None
GWAS
  • Age-related nuclear cataracts ( 24951543 )
  • Arterial stiffness ( 20031579 )
  • Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833 )
  • Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778 )
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 )
  • Coronary heart disease ( 21378990 )
  • Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133 )
  • Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136 )
  • Hip circumference adjusted for BMI ( 34021172 )
  • Hip index ( 34021172 )
  • Intraocular pressure ( 31959993 29785010 )
  • Lateral ventricle volume ( 31530798 )
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )
  • Lymphocyte count ( 32888494 )
  • Mean platelet volume ( 32888494 )
  • Metabolite levels ( 23823483 )
  • Monocyte count ( 32888494 27863252 )
  • Myocardial infarction ( 33532862 26343387 )
  • Night sleep phenotypes ( 27126917 )
  • Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 )
  • Obesity-related traits ( 23251661 )
  • Peripheral artery disease ( 31285632 )
  • Platelet count ( 32888494 )
  • Platelet distribution width ( 32888494 )
  • Plateletcrit ( 32888494 )
  • Pulse pressure ( 30578418 )
  • Stroke ( 30383316 )
  • Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 )
  • Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
  • Waist-hip index ( 34021172 )
  • Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 )
  • HDL cholesterol levels ( 32203549 )
  • Hemoglobin ( 32888494 )
  • Lung function (FEV1) ( 30061609 )
  • Malaria ( 31844061 )
  • Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952 )
  • Panic disorder ( 31712720 )
  • Red cell distribution width ( 32888494 )
  • Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 )
Novel Interactors 1 novel interactors: CXCR4 None recorded
Interacting Genes 30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1 163 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CREBBP CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NFE2L2 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TAPT1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4
Entrez ID 1282 4086
HPRD ID 00359 03356
Ensembl ID ENSG00000187498 ENSG00000170365
Uniprot IDs A5PKV2 P02462 Q15797
PDB IDs 1LI1 5NAX 5NAY 6MPX 1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK
GO Terms Enriched among Interactors