COL4A1 and NID1

Number of citations of the paper that reports this interaction (PMID 2506015)
29

Data Source:
HPRD (in vitro)

		COL4A1	NID1
Gene Name		collagen, type IV, alpha 1	nidogen 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Basement Membrane Basal Lamina Extracellular Matrix Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding	Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors	Laminin interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)	Cutaneous nevi ( 21478494)
Protein-Protein Interactions		27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1	21 interactors: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		1282	4811
HPRD ID		00359	00574
Ensembl ID		ENSG00000187498	ENSG00000116962
Uniprot IDs		P02462	P14543
PDB IDs		1LI1	1NDX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cell Adhesion Regulation Of Body Fluid Levels Cell-substrate Adhesion Blood Coagulation Hemostasis Blood Vessel Development Vasculature Development Cell-matrix Adhesion Platelet Degranulation Locomotion Wound Healing Chemotaxis Platelet Activation Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Blood Vessel Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Axonogenesis Platelet Aggregation Cardiovascular System Development Tissue Development Retinal Blood Vessel Morphogenesis Endochondral Ossification Axon Development Substrate Adhesion-dependent Cell Spreading Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-substrate Junction Assembly Neuron Projection Morphogenesis Vesicle-mediated Transport Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Developmental Process Collagen Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Lipoprotein Metabolic Process Multicellular Organismal Development
Tagcloud ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Difference) ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	accordance biogenesis bound brains clip details enriched immunoprecipitation intron linking messenger mirna mirnas neurexin neurodegeneration neurodevelopmental neurological nrxn1 pirnas processed reexamine represses rnas seq srnas systematically tar tardbp tdp
Tagcloud (Intersection) ?