COL4A1 and ACHE

Number of citations: 0 (PubMedID 12524166)
Data Source: HPRD (in vitro)

		COL4A1	ACHE
Name		collagen type IV alpha 1 chain	acetylcholinesterase (Yt blood group)
Structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Neuromuscular Junction Synaptic Cleft Synapse Perinuclear Region Of Cytoplasm Side Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Amyloid-beta Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Identical Protein Binding Protein Homodimerization Activity Laminin Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development Acetylcholine Catabolic Process Cell Adhesion Nervous System Development Synapse Assembly Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Amyloid Precursor Protein Metabolic Process Positive Regulation Of Protein Secretion Retina Development In Camera-type Eye Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
Drugs		None	Choline Tacrine Dipivefrin Gallamine triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Ranitidine Ethanol Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Neostigmine Monoisopropylphosphorylserine Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4aS,6R,8aS)-11-[8-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium Methylphosphinate Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium beta-L-fucose Huperzine B M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene N-acetyl-alpha-D-glucosamine 2-(N-morpholino)ethanesulfonic acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine NAP-226-90 (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM Zanapezil Huperzine A Phenserine Itopride Ganstigmine Hydroxy(oxo)(2-{(1S)-2,2,2-trifluoro-1-[2-(trimethylarsonio)ethoxy]ethyl}phenyl)ammonium 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (3,4,8b-Trimethyl-3-oxido-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-3-ium-7-yl) N-(2-ethylphenyl)carbamate Methylthioninium Diethylene glycol diethyl ether 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM Dimetacrine Terpinen-4-ol Tyrothricin Choline salicylate
Diseases		Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly	None
GWAS		Age-related nuclear cataracts ( 24951543 ) Arterial stiffness ( 20031579 ) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833 ) Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133 ) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Intraocular pressure ( 31959993 29785010 ) Lateral ventricle volume ( 31530798 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 27863252 ) Myocardial infarction ( 33532862 26343387 ) Night sleep phenotypes ( 27126917 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Obesity-related traits ( 23251661 ) Peripheral artery disease ( 31285632 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30578418 ) Stroke ( 30383316 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172 )	Bipolar disorder ( 31043756 ) Body mass index ( 29273807 ) Diastolic blood pressure ( 30578418 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heart rate ( 23583979 ) Heart rate increase in response to exercise ( 29497042 ) Heart rate response to recovery post exercise ( 29769521 ) Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) Heel bone mineral density ( 30598549 ) Hemoglobin levels ( 32327693 ) Nonunion in individuals with fractures ( 30680360 ) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020 ) Pulse pressure ( 27841878 ) Resting heart rate ( 27798624 ) Type 2 diabetes ( 21490949 )
Novel Interactors		1 novel interactors: CXCR4	1 novel interactors: CDK6
Interacting Genes		30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1	8 interacting genes: APP COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1
Entrez ID		1282	43
HPRD ID		00359	00010
Ensembl ID		ENSG00000187498	ENSG00000087085
Uniprot IDs		A5PKV2 P02462	P22303
PDB IDs		1LI1 5NAX 5NAY 6MPX	1B41 1F8U 1VZJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8 4M0E 4M0F 4PQE 5FOQ 5FPQ 5HF5 5HF6 5HF8 5HF9 5HFA 5HQ3 6CQT 6CQU 6CQV 6CQW 6CQX 6CQY 6CQZ 6F25 6NEA 6NTG 6NTH 6NTK 6NTL 6NTM 6NTN 6NTO 6O4W 6O4X 6O50 6O52 6O5R 6O5S 6O5V 6O66 6O69 6U34 6U37 6U3P 6WUV 6WUY 6WUZ 6WV1 6WVC 6WVO 6WVP 6WVQ 6ZWE 7D9O 7D9P 7D9Q 7E3D 7E3H 7RB5 7RB6 7RB7 7XN1 8AEN 8AEV 8DT2 8DT4 8DT5 8DT7
GO Terms Enriched among Interactors		Extracellular Region Extracellular Matrix Basement Membrane Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Binding Acute-phase Response Extracellular Exosome Cell Adhesion Endoplasmic Reticulum Lumen Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis High-density Lipoprotein Particle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycosaminoglycan Binding Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Regulation Of Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Developmental Process Endodermal Cell Differentiation Calcium Ion Binding Golgi Lumen Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Proteoglycan Binding Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neurogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Inflammatory Response Negative Regulation Of Platelet Activation Regulation Of Wound Healing Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Laminin Binding Negative Regulation Of Wound Healing Bone Development Positive Regulation Of Nervous System Development	Basement Membrane Extracellular Matrix Structural Constituent Laminin-1 Complex Laminin Complex Retinal Blood Vessel Morphogenesis Glycosphingolipid Binding Regulation Of Basement Membrane Organization Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Integrin-mediated Signaling Pathway Extracellular Matrix Regulation Of Integrin-mediated Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Anatomical Structure Morphogenesis Positive Regulation Of Toll Signaling Pathway Glial Cell Development Endoplasmic Reticulum Lumen Cyclin D2-CDK6 Complex Morphogenesis Of An Epithelium Tube Morphogenesis Laminin-8 Complex Regulation Of Extracellular Matrix Organization Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Embryonic Heart Tube Formation Collagen Trimer Positive Regulation Of Muscle Cell Differentiation Acetylcholine Receptor Activator Activity PTB Domain Binding Cellular Developmental Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Enzyme Binding Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Tissue Morphogenesis