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COL4A1 and THBS1
Number of citations of the paper that reports this interaction (PubMedID
3571333
)
41
Data Source:
BioGRID
(pull down)
COL4A1
THBS1
Description
collagen type IV alpha 1 chain
thrombospondin 1
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Collagen Type IV Trimer
Basement Membrane
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Extracellular Exosome
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Platelet-derived Growth Factor Binding
Phosphatidylserine Binding
Fibronectin Binding
Protease Binding
Endopeptidase Inhibitor Activity
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Protein Homodimerization Activity
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Fibrinogen Binding
Collagen V Binding
Biological Process
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Brain Development
Neuromuscular Junction Development
Epithelial Cell Differentiation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Blood Vessel Morphogenesis
Retinal Blood Vessel Morphogenesis
Renal Tubule Morphogenesis
Cellular Response To Amino Acid Stimulus
Basement Membrane Organization
Angiogenesis
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Positive Regulation Of Immune System Process
Apoptotic Process
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Adhesion
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Regulation Of Cell-substrate Adhesion
Cell Migration
Negative Regulation Of Angiogenesis
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Nitric Oxide-cGMP-mediated Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Blood Vessel Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
Collagen chain trimerization
Attachment of bacteria to epithelial cells
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes PpS
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
Brain small vessel disease with Axenfeld-Rieger anomaly
Porencephaly
GWAS
Age-related nuclear cataracts (
24951543
)
Arterial stiffness (
20031579
)
Behavioral disturbance or psychiatric symptoms and prion disease (
25897833
)
Coronary artery disease (
32469254
33020668
24262325
26343387
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary heart disease (
21378990
)
Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension (
31754133
)
Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) (
30920136
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Intraocular pressure (
31959993
29785010
)
Lateral ventricle volume (
31530798
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
27863252
)
Myocardial infarction (
33532862
26343387
)
Night sleep phenotypes (
27126917
)
Non-lobar intracerebral hemorrhage (MTAG) (
31430377
)
Obesity-related traits (
23251661
)
Peripheral artery disease (
31285632
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
30578418
)
Stroke (
30383316
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
28552196
34021172
)
Cortical volume (
32963231
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Interacting Genes
30 interacting genes:
ACHE
APCS
APP
BGN
BMP3
CD93
COL18A1
COL4A2
COL7A1
DCN
DISC1
FBLN2
FN1
HABP2
MAG
MATN2
MMP9
NID1
NID2
OSM
PDGFA
PDGFB
SAA1
SAA2
SAA4
SERPINE2
SMAD1
TGFBI
TGM2
THBS1
52 interacting genes:
APP
BGN
CALCR
CALR
CD36
CD47
CFH
COL11A1
COL18A1
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
COL7A1
CORO1A
CTSG
DCN
DHFR
DYRK1A
ELANE
F2
FBN2
FGA
FGF2
FN1
HRG
HSP90AA1
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
PLSCR1
SCARB2
SPARC
TFPI
TGFB1
TGM2
TNFAIP6
TNFRSF11B
WEE2-AS1
WWP2
Entrez ID
1282
7057
HPRD ID
00359
01765
Ensembl ID
ENSG00000187498
ENSG00000137801
Uniprot IDs
A5PKV2
P02462
P07996
PDB IDs
1LI1
5NAX
5NAY
6MPX
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
7YYK
Enriched GO Terms of Interacting Partners
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Extracellular Region
Extracellular Matrix
Basement Membrane
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Extracellular Matrix Binding
Acute-phase Response
Extracellular Exosome
Cell Adhesion
Endoplasmic Reticulum Lumen
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
High-density Lipoprotein Particle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Glycosaminoglycan Binding
Regulation Of Cell Adhesion
Acute Inflammatory Response
Platelet Alpha Granule Lumen
Regulation Of Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Developmental Process
Endodermal Cell Differentiation
Calcium Ion Binding
Golgi Lumen
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Proteoglycan Binding
Response To Wounding
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Neurogenesis
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell-substrate Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Multicellular Organismal Process
Inflammatory Response
Negative Regulation Of Platelet Activation
Regulation Of Wound Healing
Platelet Alpha Granule
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Laminin Binding
Negative Regulation Of Wound Healing
Bone Development
Positive Regulation Of Nervous System Development
Extracellular Matrix
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Platelet-derived Growth Factor Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Regulation Of Cell Motility
Regulation Of Locomotion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Multicellular Organismal Process
Collagen Trimer
Regulation Of Signal Transduction
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Endodermal Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Locomotion
Fibrillar Collagen Trimer
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Heparin Binding
Regulation Of Hemostasis
Cell Surface
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Anatomical Structure Formation Involved In Morphogenesis
Negative Regulation Of Coagulation
Tissue Remodeling
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Wound Healing
Animal Organ Morphogenesis
Response To Wounding
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Coagulation
Regulation Of Cell-substrate Adhesion
Platelet Activation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Multicellular Organismal Process
Hemostasis
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Tagcloud (Intersection)
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