COL4A1 and MATN2

Number of citations of the paper that reports this interaction (PMID 12180907)
9

Data Source:
HPRD (in vivo)

		COL4A1	MATN2
Gene Name		collagen, type IV, alpha 1	matrilin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding	Molecular_function Calcium Ion Binding Protein Binding
	Biological Process	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Neuron Migration Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)
Protein-Protein Interactions		27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1	18 interactors: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN3 MATN4
Entrez ID		1282	4147
HPRD ID		00359	03660
Ensembl ID		ENSG00000187498	ENSG00000132561
Uniprot IDs		P02462	O00339 Q8N2G3
PDB IDs		1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process System Development Multicellular Organismal Development Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Organ Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Axon Guidance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Development Locomotion Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Bone Trabecula Formation Axonogenesis Cell Differentiation Neuron Development Axon Development Movement Of Cell Or Subcellular Component Chemotaxis Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Generation Of Neurons Bone Trabecula Morphogenesis Neuron Differentiation Neurogenesis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Projection Organization Catabolic Process Response To External Stimulus Synapse Organization Cardiovascular System Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endodermal Cell Differentiation Blood Vessel Development Vasculature Development Trabecula Morphogenesis Skeletal System Development Neuromuscular Junction Development
Tagcloud ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise
Tagcloud (Difference) ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise
Tagcloud (Intersection) ?