COL4A1 and COL4A2

Number of citations of the paper that reports this interaction (PMID 12011424)
24

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		COL4A1	COL4A2
Gene Name		collagen, type IV, alpha 1	collagen, type IV, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Angiogenesis Transcription, DNA-templated Receptor-mediated Endocytosis Axon Guidance Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)	Coronary artery calcification ( 22144573) Coronary heart disease ( 21378990)
Protein-Protein Interactions		27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1	23 interactors: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FAM46A FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TGFBI TK1
Entrez ID		1282	1284
HPRD ID		00359	00355
Ensembl ID		ENSG00000187498	ENSG00000134871
Uniprot IDs		P02462	P08572
PDB IDs		1LI1	1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Chemotaxis Anatomical Structure Development System Development Nervous System Development Axon Guidance Cell Morphogenesis Involved In Differentiation Hemostasis Generation Of Neurons Developmental Process Multicellular Organismal Development Neurogenesis Cell Differentiation Locomotion Extracellular Matrix Disassembly Axonogenesis Response To External Stimulus Axon Development Regulation Of Body Fluid Levels Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To Wounding Blood Coagulation Endodermal Cell Differentiation Acute-phase Response Platelet Activation Neuron Projection Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Projection Morphogenesis Cell Development Peptide Cross-linking Reproductive Process Cell Part Morphogenesis Seminal Vesicle Epithelium Development Fetal Process Involved In Parturition Dendrite Regeneration Mating Neuromuscular Junction Development Leukocyte Migration Regulation Of Pathway-restricted SMAD Protein Phosphorylation Endoderm Formation Neuron Development Collagen Catabolic Process Regulation Of Binding Behavior
Tagcloud ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Difference) ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Intersection) ?