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COL4A1 and SAA2
Number of citations of the paper that reports this interaction (PubMedID
8995276
)
0
Data Source:
HPRD
(in vitro)
COL4A1
SAA2
Description
collagen type IV alpha 1 chain
serum amyloid A2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Collagen Type IV Trimer
Basement Membrane
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Region
High-density Lipoprotein Particle
Extracellular Exosome
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Platelet-derived Growth Factor Binding
Protein Binding
Biological Process
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Brain Development
Neuromuscular Junction Development
Epithelial Cell Differentiation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Blood Vessel Morphogenesis
Retinal Blood Vessel Morphogenesis
Renal Tubule Morphogenesis
Cellular Response To Amino Acid Stimulus
Basement Membrane Organization
Acute-phase Response
Pathways
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
Collagen chain trimerization
Attachment of bacteria to epithelial cells
Drugs
Diseases
Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
Brain small vessel disease with Axenfeld-Rieger anomaly
Porencephaly
GWAS
Age-related nuclear cataracts (
24951543
)
Arterial stiffness (
20031579
)
Behavioral disturbance or psychiatric symptoms and prion disease (
25897833
)
Coronary artery disease (
32469254
33020668
24262325
26343387
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary heart disease (
21378990
)
Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension (
31754133
)
Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) (
30920136
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Intraocular pressure (
31959993
29785010
)
Lateral ventricle volume (
31530798
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
27863252
)
Myocardial infarction (
33532862
26343387
)
Night sleep phenotypes (
27126917
)
Non-lobar intracerebral hemorrhage (MTAG) (
31430377
)
Obesity-related traits (
23251661
)
Peripheral artery disease (
31285632
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
30578418
)
Stroke (
30383316
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
28552196
34021172
)
Interacting Genes
30 interacting genes:
ACHE
APCS
APP
BGN
BMP3
CD93
COL18A1
COL4A2
COL7A1
DCN
DISC1
FBLN2
FN1
HABP2
MAG
MATN2
MMP9
NID1
NID2
OSM
PDGFA
PDGFB
SAA1
SAA2
SAA4
SERPINE2
SMAD1
TGFBI
TGM2
THBS1
4 interacting genes:
CIDEB
COL4A1
LAMA1
TEAD2
Entrez ID
1282
6289
HPRD ID
00359
00098
Ensembl ID
ENSG00000187498
ENSG00000134339
Uniprot IDs
A5PKV2
P02462
P0DJI9
PDB IDs
1LI1
5NAX
5NAY
6MPX
Enriched GO Terms of Interacting Partners
?
Extracellular Region
Extracellular Matrix
Basement Membrane
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Extracellular Matrix Binding
Acute-phase Response
Extracellular Exosome
Cell Adhesion
Endoplasmic Reticulum Lumen
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
High-density Lipoprotein Particle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Glycosaminoglycan Binding
Regulation Of Cell Adhesion
Acute Inflammatory Response
Platelet Alpha Granule Lumen
Regulation Of Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Developmental Process
Endodermal Cell Differentiation
Calcium Ion Binding
Golgi Lumen
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Proteoglycan Binding
Response To Wounding
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Neurogenesis
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell-substrate Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Multicellular Organismal Process
Inflammatory Response
Negative Regulation Of Platelet Activation
Regulation Of Wound Healing
Platelet Alpha Granule
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Laminin Binding
Negative Regulation Of Wound Healing
Bone Development
Positive Regulation Of Nervous System Development
Retinal Blood Vessel Morphogenesis
Retina Vasculature Morphogenesis In Camera-type Eye
Morphogenesis Of An Epithelium
Tube Morphogenesis
Tissue Morphogenesis
Basement Membrane
Epithelial Tube Morphogenesis
Blood Vessel Morphogenesis
Extracellular Matrix Structural Constituent
Branching Morphogenesis Of An Epithelial Tube
Morphogenesis Of A Branching Epithelium
Morphogenesis Of A Branching Structure
TEAD-YAP Complex
Laminin-1 Complex
Laminin-3 Complex
Lateral Mesoderm Development
Laminin Complex
Lipid Droplet Fusion
Collagen Type IV Trimer
Glycosphingolipid Binding
Paraxial Mesoderm Development
Regulation Of Basement Membrane Organization
Protein Complex Involved In Cell-matrix Adhesion
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Platelet-derived Growth Factor Binding
Notochord Development
Very-low-density Lipoprotein Particle Assembly
Branching Involved In Salivary Gland Morphogenesis
Lipid Transfer Activity
Positive Regulation Of Integrin-mediated Signaling Pathway
Epithelial Cell Differentiation
COPI-coated Vesicle
Collagen-activated Signaling Pathway
Extracellular Matrix
Signal Transduction
Renal Tubule Morphogenesis
COPII Vesicle Coat
Establishment Of Epithelial Cell Apical/basal Polarity
COPII-coated Vesicle Cargo Loading
Morphogenesis Of An Epithelial Sheet
Phosphatidic Acid Binding
Plasma Lipoprotein Particle Assembly
Establishment Of Apical/basal Cell Polarity
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Epithelial Tube Branching Involved In Lung Morphogenesis
Regulation Of Integrin-mediated Signaling Pathway
Polarized Epithelial Cell Differentiation
Execution Phase Of Apoptosis
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Tagcloud (Intersection)
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