COL4A1 and SAA4

Number of citations of the paper that reports this interaction (PubMedID 8995276)
0

Data Source:
HPRD (in vitro)

		COL4A1	SAA4
Description		collagen type IV alpha 1 chain	serum amyloid A4, constitutive
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region High-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Protein Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Acute-phase Response
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases		Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly
GWAS		Age-related nuclear cataracts ( 24951543) Arterial stiffness ( 20031579) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 31959993 29785010) Lateral ventricle volume ( 31530798) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Myocardial infarction ( 33532862 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Peripheral artery disease ( 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Stroke ( 30383316) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1	3 interacting genes: CIDEB COL4A1 NUDT9P1
Entrez ID		1282	6291
HPRD ID		00359	00099
Ensembl ID		ENSG00000187498	ENSG00000148965
Uniprot IDs		A5PKV2 P02462	P35542
PDB IDs		1LI1 5NAX 5NAY 6MPX
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Matrix Basement Membrane Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Binding Acute-phase Response Extracellular Exosome Cell Adhesion Endoplasmic Reticulum Lumen Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis High-density Lipoprotein Particle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycosaminoglycan Binding Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Regulation Of Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Developmental Process Endodermal Cell Differentiation Calcium Ion Binding Golgi Lumen Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Proteoglycan Binding Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neurogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Inflammatory Response Negative Regulation Of Platelet Activation Regulation Of Wound Healing Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Laminin Binding Negative Regulation Of Wound Healing Bone Development Positive Regulation Of Nervous System Development	Collagen-activated Signaling Pathway Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Renal Tubule Morphogenesis Platelet-derived Growth Factor Binding Retinal Blood Vessel Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Collagen Type IV Trimer COPI-coated Vesicle COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion COPII-coated Vesicle Cargo Loading Very-low-density Lipoprotein Particle Assembly Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Branching Involved In Blood Vessel Morphogenesis Neuromuscular Junction Development Extracellular Matrix Structural Constituent Conferring Tensile Strength Basement Membrane Organization Lipid Droplet Organization Lipid Storage Intermembrane Lipid Transfer Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process
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