COL4A1 and FBLN2

Number of citations of the paper that reports this interaction (PMID 7500359)
18

Data Source:
HPRD (in vivo)

		COL4A1	FBLN2
Gene Name		collagen, type IV, alpha 1	fibulin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)	Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1	22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408
Entrez ID		1282	2199
HPRD ID		00359	00630
Ensembl ID		ENSG00000187498	ENSG00000163520
Uniprot IDs		P02462	F5H1F3 P98095 Q86V58 Q9Y3V7
PDB IDs		1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis
Tagcloud ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Difference) ?		arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Intersection) ?		excluded