FGD4 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 9668039)
0

Data Source:
HPRD (in vitro)

		FGD4	ACTA1
Description		FYVE, RhoGEF and PH domain containing 4	actin alpha 1, skeletal muscle
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Filopodium Cell Projection	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Figural/spatial cognitive ability ( 31620175) Health literacy ( 31250787) Mean platelet volume ( 27863252 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		3 interacting genes: ACTA1 BBLN CDC42	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		121512	58
HPRD ID		16891	00030
Ensembl ID		ENSG00000139132	ENSG00000143632
Uniprot IDs		B7Z493 B7Z8F9 E9PJX4 E9PQT1 F8VWL3 F8W1R0 Q49A55 Q96M96	P68133
PDB IDs			7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Filopodium Cytoskeleton Actin Filament Organization Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Subapical Part Of Cell Multinuclear Osteoclast Differentiation Striated Muscle Thin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Leading Edge Membrane Leukocyte Differentiation Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Intermediate Filament Bundle Assembly Endothelin Receptor Signaling Pathway Positive Regulation Of Pseudopodium Assembly Golgi Localization Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Kinetochore Microtubule Myosin Binding Bone Resorption Cellular Developmental Process Positive Regulation Of Lamellipodium Assembly	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
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