FGD4

Description		FYVE, RhoGEF and PH domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Filopodium Cell Projection
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Figural/spatial cognitive ability ( 31620175) Health literacy ( 31250787) Mean platelet volume ( 27863252 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		3 interacting genes: ACTA1 BBLN CDC42
Entrez ID		121512
HPRD ID		16891
Ensembl ID		ENSG00000139132
Uniprot IDs		B7Z493 B7Z8F9 E9PJX4 E9PQT1 F8VWL3 F8W1R0 Q49A55 Q96M96
PDB IDs
Enriched GO Terms of Interacting Partners?		Supramolecular Fiber Organization Filopodium Cytoskeleton Actin Filament Organization Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Subapical Part Of Cell Multinuclear Osteoclast Differentiation Striated Muscle Thin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Leading Edge Membrane Leukocyte Differentiation Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Intermediate Filament Bundle Assembly Endothelin Receptor Signaling Pathway Positive Regulation Of Pseudopodium Assembly Golgi Localization Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Kinetochore Microtubule Myosin Binding Bone Resorption Cellular Developmental Process Positive Regulation Of Lamellipodium Assembly
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