IRAK3 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 10383454)
0

Data Source:
HPRD (in vivo)

		IRAK3	IRAK1
Description		interleukin 1 receptor associated kinase 3	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Response to esketamine in treatment resistant depression ( 32724131) Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)	Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2
Entrez ID		11213	3654
HPRD ID		05123	02235
Ensembl ID		ENSG00000090376	ENSG00000184216
Uniprot IDs		Q9Y616	D3YTB5 P51617
PDB IDs		5UKE 6RUU 6ZIW	6BFN
Enriched GO Terms of Interacting Partners?		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication
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