IRAK3 and NSA2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IRAK3	NSA2
Name		interleukin 1 receptor associated kinase 3	NSA2 ribosome biogenesis factor
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Nucleolus Preribosome Preribosome, Large Subunit Precursor Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	RNA Binding
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA RRNA Processing Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	None
Drugs		Fostamatinib	None
GWAS		Response to esketamine in treatment resistant depression ( 32724131 ) Smooth-surface caries ( 24556642 ) White blood cell count (basophil) ( 29403010 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	1 interacting genes: IRAK3
Entrez ID		11213	10412
HPRD ID		05123	18191
Ensembl ID		ENSG00000090376	ENSG00000164346
Uniprot IDs		Q9Y616	A0A0A0MQZ6 O95478 Q5J7U2
PDB IDs		5UKE 6RUU 6ZIW	8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
GO Terms Enriched among Interactors		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Positive Regulation Of Macrophage Tolerance Induction Toll Signaling Pathway Positive Regulation Of Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Response To Peptidoglycan MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Tolerance Induction Negative Regulation Of Interleukin-12 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Macrophage Cytokine Production Negative Regulation Of Cytokine Production Involved In Immune Response Regulation Of Toll-like Receptor Signaling Pathway Response To Exogenous DsRNA Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production Response To DsRNA Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-12 Production Negative Regulation Of Protein-containing Complex Disassembly Response To Interleukin-1 Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Protein Catabolic Process Regulation Of Interleukin-6 Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Immune Response Magnesium Ion Binding Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction