IRAK3 and CDCA5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IRAK3	CDCA5
Gene Name		interleukin-1 receptor-associated kinase 3	cell division cycle associated 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Interleukin-1 Receptor Complex	Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Cohesin Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Cell Division Regulation Of Cohesin Localization To Chromatin
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Establishment of Sister Chromatid Cohesion Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase S Phase Mitotic Metaphase and Anaphase M Phase Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	7 interactors: CDK1 IRAK3 KDM1A RPAIN SENP2 TTLL3 XRCC6
Entrez ID		11213	113130
HPRD ID		05123	13016
Ensembl ID		ENSG00000090376	ENSG00000146670
Uniprot IDs		Q9Y616	Q96FF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction	Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Binding Negative Regulation Of Intracellular Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Macrophage Tolerance Induction Regulation Of Primitive Erythrocyte Differentiation Pronuclear Fusion Negative Regulation Of Binding Toll-like Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Repair Positive Regulation Of Gene Expression Protein Polyglycylation Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Cellular Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Protein Modification Process Activation Of Innate Immune Response Regulation Of Protein Binding Cellular Hyperosmotic Salinity Response Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Development Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Innate Immune Response Regulation Of Cellular Protein Metabolic Process Protein Desumoylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To X-ray Positive Regulation Of Immune System Process Immune System Process Negative Regulation Of Chromatin Binding Regulation Of Schwann Cell Differentiation DNA Recombination Regulation Of Protein Metabolic Process Histone H3-K9 Demethylation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K4 Demethylation Establishment Of Integrated Proviral Latency Regulation Of Innate Immune Response Regulation Of Binding Chromosome Organization
Tagcloud ?		a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Difference) ?		a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Intersection) ?