IRAK3 and ADH1B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IRAK3	ADH1B
Name		interleukin 1 receptor associated kinase 3	alcohol dehydrogenase 1B (class I), beta polypeptide
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Ciliary Basal Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Alcohol Dehydrogenase (NAD+) Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Retinoid Metabolic Process Lipid Metabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	Ethanol oxidation
Drugs		Fostamatinib	NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin
GWAS		Response to esketamine in treatment resistant depression ( 32724131 ) Smooth-surface caries ( 24556642 ) White blood cell count (basophil) ( 29403010 )	Adult body size ( 32376654 ) Alcohol consumption ( 31358974 28937693 23743675 ) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404 ) Alcohol consumption (drinks per week) ( 30643258 30679032 28485404 31959922 ) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841 ) Alcohol consumption in current drinkers ( 28937693 ) Alcohol dependence ( 33290381 24166409 31090166 28714907 23456092 31591379 22004471 ) Alcohol dependence (desire to cut drinking) ( 31090166 ) Alcohol dependence (tolerance) ( 31090166 ) Alcohol dependence symptom count ( 31090166 ) Alcohol use disorder ( 30940813 ) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876 ) Alcohol use disorder (dependence and problematic use scores) ( 30336701 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Bitter alcoholic beverage consumption ( 31046077 ) Blood urea nitrogen levels ( 31152163 ) Esophageal cancer ( 19698717 ) Esophageal cancer (alcohol interaction) ( 22960999 ) Gout ( 33832965 ) Gout vs asymptomatic hyperuricemia ( 33832965 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Initial pursuit acceleration ( 29064472 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung cancer ( 28604730 ) Maximum habitual alcohol consumption ( 31151762 ) Metabolite levels ( 23823483 ) Oral cavity and pharyngeal cancer ( 27749845 21437268 ) Oral cavity cancer ( 27749845 ) Oropharynx cancer ( 27749845 ) Problematic alcohol use ( 32451486 ) Regular attendance at a pub or social club ( 29970889 ) Relative fat intake ( 32393786 ) Relative protein intake ( 32393786 ) Reticulocyte count ( 32888494 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3
Entrez ID		11213	125
HPRD ID		05123	00065
Ensembl ID		ENSG00000090376	ENSG00000196616
Uniprot IDs		Q9Y616	D6RHZ6 P00325 V9HW50
PDB IDs		5UKE 6RUU 6ZIW	1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
GO Terms Enriched among Interactors		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Molecular Adaptor Activity Response To Peptide Response To Cytokine Negative Regulation Of Translation In Response To Oxidative Stress Protein Homodimerization Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Component Organization Cortical Microtubule Plus-end IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Positive Regulation Of Macrophage Tolerance Induction Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cobalt Ion Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Localization To Chromosome, Telomeric Region Ubiquitin-like Protein Ligase Activity Negative Regulation Of Translation Regulation Of Cellular Component Organization Negative Regulation Of Translational Initiation In Response To Stress Oncogene-induced Cell Senescence Negative Regulation Of Growth Positive Regulation Of Apoptotic Process Involved In Morphogenesis PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Translational Elongation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Gastrulation Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding Toll Signaling Pathway Rhythmic Process Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Microtubule Nucleation Protein Tyrosine Kinase Inhibitor Activity Positive Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Translation In Response To Stress Positive Regulation Of Mitochondrial Depolarization Regulation Of Translational Initiation In Response To Stress SUMO Binding Astral Microtubule Organization Regulation Of Translational Elongation Regulation Of Golgi To Plasma Membrane Protein Transport Homeostatic Process Protein Heterodimerization Activity Negative Regulation Of Cytokine Production Positive Regulation Of Membrane Depolarization