IRAK3 and CD14

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IRAK3	CD14
Description		interleukin 1 receptor associated kinase 3	CD14 molecule
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions
Drugs		Fostamatinib	Atibuclimab
Diseases			Asthma
GWAS		Response to esketamine in treatment resistant depression ( 32724131) Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)	Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		11213	929
HPRD ID		05123	01151
Ensembl ID		ENSG00000090376	ENSG00000170458
Uniprot IDs		Q9Y616	P08571
PDB IDs		5UKE 6RUU 6ZIW	4GLP
Enriched GO Terms of Interacting Partners?		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction
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