IRAK3 and TRAF6

Number of citations of the paper that reports this interaction (PMID 10383454)
63

Data Source:
HPRD (in vivo)

		IRAK3	TRAF6
Gene Name		interleukin-1 receptor-associated kinase 3	TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Interleukin-1 Receptor Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Lipid Particle Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane CD40 Receptor Complex Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Ossification Neural Tube Closure Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Complex Assembly I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	NF-kB is activated and signals survival TRAF6 mediated induction of TAK1 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation Regulated proteolysis of p75NTR IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	144 interactors: ABL1 APP ATM ATP6V1E1 ATXN3 BECN1 BMPR1B CALCOCO2 CASP8 CAV1 CBL CD40 CYLD ECSIT EDA2R EDARADD FHL2 FYN GTF2I HIF1A HSPA4 IKBKG IL17RB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MAVS MBP MCL1 MEOX2 MTOR NGFR NGFRAP1 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PELI3 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RIPK2 RNF114 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STRADB STUB1 SYK TAB1 TAB2 TAB3 TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TMEM189-UBE2V1 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 UBB UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UEVLD USP1 USP15 USP2 USP21 USP39 USP4 USP5 USP7 VPS52 XIAP YBX1 YES1 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		11213	7189
HPRD ID		05123	03833
Ensembl ID		ENSG00000090376
Uniprot IDs		Q9Y616	Q9Y4K3
PDB IDs			1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction	Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Communication Signal Transduction Signaling Immune System Process Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Response To Organic Substance Cell Death Death Cellular Protein Metabolic Process Innate Immune Response Activation Of Protein Kinase Activity Programmed Cell Death Cellular Response To Organic Substance Cellular Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process
Tagcloud ?		a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction
Tagcloud (Difference) ?		a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 trafs	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf5 transduction
Tagcloud (Intersection) ?		traf6