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IRAK3 and TICAM2
Number of citations of the paper that reports this interaction (PubMedID
12721283
)
0
Data Source:
HPRD
(in vitro, in vivo)
IRAK3
TICAM2
Description
interleukin 1 receptor associated kinase 3
TIR domain containing adaptor molecule 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Phagocytic Cup
Cytoplasm
Endosome
Early Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Endosome Membrane
Membrane
Secretory Granule Membrane
Early Endosome Membrane
Late Endosome Membrane
Cell Projection
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Binding
Signaling Adaptor Activity
Molecular Adaptor Activity
Biological Process
Positive Regulation Of Cytokine Production
Negative Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
Toll Signaling Pathway
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAPK Cascade
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Immune System Process
Phagocytosis
Inflammatory Response
Signal Transduction
Positive Regulation Of Type I Interferon Production
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAM-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Response To Other Organism
Cellular Response To Lipopolysaccharide
Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Neutrophil degranulation
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Drugs
Fostamatinib
Diseases
GWAS
Response to esketamine in treatment resistant depression (
32724131
)
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29679657
)
Response to antidepressants (symptom improvement) (
29160301
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
19 interacting genes:
FTH1
IL1R1
IL1RAP
IRAK1
IRAK2
IRAK3
IRAK4
IRF3
IRF7
MEOX2
NTAQ1
OPN1LW
PIAS2
SARM1
TICAM1
TIRAP
TLR3
TLR4
TRAF6
Entrez ID
11213
353376
HPRD ID
05123
16313
Ensembl ID
ENSG00000090376
ENSG00000243414
Uniprot IDs
Q9Y616
Q86XR7
PDB IDs
5UKE
6RUU
6ZIW
2M1W
9DKI
9DLG
Enriched GO Terms of Interacting Partners
?
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Endosome Membrane
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Type I Interferon Production
Toll Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Activation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Positive Regulation Of Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Lipopolysaccharide
Cellular Response To Oxygen-containing Compound
Immune Response-activating Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Signaling Adaptor Activity
Response To Interleukin-1
Regulation Of Immune Response
Positive Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Endolysosomal Toll-like Receptor Signaling Pathway
Cellular Response To Lipid
Non-canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Regulation Of Immune System Process
Regulation Of Defense Response
Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Defense Response
Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Defense Response To Symbiont
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Activation Of Innate Immune Response
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Interleukin-1-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Defense Response
Regulation Of Defense Response
Positive Regulation Of Immune Response
Regulation Of Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Type I Interferon Production
Positive Regulation Of Cytokine Production
Immune Response
Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Toll Signaling Pathway
Regulation Of Interferon-beta Production
Endolysosomal Toll-like Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Defense Response To Symbiont
Defense Response To Other Organism
Response To External Biotic Stimulus
Regulation Of Interleukin-6 Production
Defense Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Response To Other Organism
Endosome Membrane
Positive Regulation Of Interferon-beta Production
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