IRAK3 and HOXB7

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IRAK3	HOXB7
Name		interleukin 1 receptor associated kinase 3	homeobox B7
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Cytokine Production Negative Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Toll Signaling Pathway Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAPK Cascade Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	None
Drugs		Fostamatinib	None
GWAS		Response to esketamine in treatment resistant depression ( 32724131 ) Smooth-surface caries ( 24556642 ) White blood cell count (basophil) ( 29403010 )	Hypertension ( 27618447 ) LDL cholesterol levels ( 32203549 ) Mean arterial pressure ( 30487518 ) Pulse pressure ( 27618447 28135244 ) Systolic blood pressure ( 27618447 30487518 )
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	13 interacting genes: APP CLK3 CREBBP CSNK2A1 EP300 GMNN HOXB6 IRAK3 NFKBIA PARP1 PBX1 PKNOX1 XRCC6
Entrez ID		11213	3217
HPRD ID		05123	00850
Ensembl ID		ENSG00000090376	ENSG00000260027
Uniprot IDs		Q9Y616	P09629
PDB IDs		5UKE 6RUU 6ZIW	Not available
GO Terms Enriched among Interactors		Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Endosome Membrane Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Toll Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Activation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Oxygen-containing Compound Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Signaling Adaptor Activity Response To Interleukin-1 Regulation Of Immune Response Positive Regulation Of Immune Response Immune Response-regulating Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Cellular Response To Lipid Non-canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Defense Response To Symbiont	Transcription Regulator Complex Regulation Of Innate Immune Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Localization To Nucleus Damaged DNA Binding Activation Of Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Defense Response Histone H3K27 Acetyltransferase Activity Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Defense Response Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Cellular Response To Radiation Positive Regulation Of DNA-templated Transcription Hemopoiesis Innate Immune Response-activating Signaling Pathway DNA-binding Transcription Factor Binding Activation Of Immune Response Canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Metabolic Process Response To Radiation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Double-strand Break Repair Innate Immune Response Activating Cell Surface Receptor Signaling Pathway