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IRAK3 and NONO
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
IRAK3
NONO
Description
interleukin 1 receptor associated kinase 3
non-POU domain containing octamer binding
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Membrane
Nuclear Matrix
Nuclear Speck
Paraspeckles
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Nucleic Acid Binding
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
Identical Protein Binding
LncRNA Binding
Biological Process
Positive Regulation Of Cytokine Production
Negative Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
Toll Signaling Pathway
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAPK Cascade
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Activation Of Innate Immune Response
Immune System Process
DNA Repair
DNA Recombination
Regulation Of DNA-templated Transcription
MRNA Processing
DNA Damage Response
Circadian Rhythm
RNA Splicing
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Cellular Response To Hypoxia
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Angiotensin
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Drugs
Fostamatinib
Diseases
GWAS
Response to esketamine in treatment resistant depression (
32724131
)
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
124 interacting genes:
APBB1
AR
BHLHE41
C11orf68
CA2
CDK1
CEBPA
DANCR
DDX6
DELEC1
ERCC6
ERG
ESR1
EWSR1
FXR2
H3-4
IL7R
IRAK3
LINC00624
LMO4
MAD1L1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYC
MYCN
OGT
ORC5
OTUD5
PDE4B
PIN1
PLEKHF2
POLR1H
POLR2A
PPP1CA
PPP1CB
PPP1CC
PRKAA2
PRPF40A
PSPC1
PTBP1
RNF8
SAMHD1
SFPQ
SMARCB1
SMARCC1
SMARCD1
SPI1
SUMO2
SYNPO
TAFAZZIN
TCERG1
UBE2I
USP11
WBP4
Entrez ID
11213
4841
HPRD ID
05123
02098
Ensembl ID
ENSG00000090376
ENSG00000147140
Uniprot IDs
Q9Y616
A0A0S2Z4Z9
Q15233
PDB IDs
5UKE
6RUU
6ZIW
3SDE
5IFM
6WMZ
7LRQ
7LRU
7PU5
Enriched GO Terms of Interacting Partners
?
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Endosome Membrane
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Type I Interferon Production
Toll Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Activation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Positive Regulation Of Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Lipopolysaccharide
Cellular Response To Oxygen-containing Compound
Immune Response-activating Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Signaling Adaptor Activity
Response To Interleukin-1
Regulation Of Immune Response
Positive Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Endolysosomal Toll-like Receptor Signaling Pathway
Cellular Response To Lipid
Non-canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Regulation Of Immune System Process
Regulation Of Defense Response
Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Defense Response
Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Defense Response To Symbiont
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Extracellular Vesicle
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Translation
Regulation Of Metabolic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cytokine Production
Negative Regulation Of Cell Motility
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Translation
Negative Regulation Of Developmental Process
Negative Regulation Of Cell Migration
Negative Regulation Of Locomotion
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Angiogenesis
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Vasculature Development
Regulation Of MRNA Stability
Regulation Of RNA Stability
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Developmental Process
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Blood Vessel Endothelial Cell Migration
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