TPPP and MAP1LC3B

Number of citations of the paper that reports this interaction (PubMedID 34084775)
67

Data Source:
BioGRID (pull down)

		TPPP	MAP1LC3B
Description		tubulin polymerization promoting protein	microtubule associated protein 1 light chain 3 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Perinuclear Region Of Cytoplasm Mitotic Spindle Microtubule Bundle Postsynaptic Golgi Apparatus	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Cytosol Cytoskeleton Microtubule Axoneme Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Mitochondrial Membrane
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Microtubule Binding Tubulin Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Ceramide Binding
	Biological Process	Microtubule Bundle Formation Oligodendrocyte Development Astral Microtubule Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Myelination Positive Regulation Of Protein Polymerization Myelin Assembly Microtubule Polymerization Oligodendrocyte Differentiation Cell Division Microtubule Nucleation By Microtubule Organizing Center Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Tubulin Deacetylation	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation
Pathways			Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Esophageal adenocarcinoma ( 27527254) Estimated glomerular filtration rate ( 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Haemorrhoidal disease ( 33888516) Idiopathic downbeat nystagmus ( 32157568) Ulcerative colitis ( 20228799 28067908)	General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: APP CDK11B DYNLL2 GAPDH GSK3B HDAC6 MAP1LC3B ROCK1 SNCA TUBB ZNF114	97 interacting genes: AAMP ABTB3 ADD1 ADNP AFTPH AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BAG6 BIRC6 BNIP3 BRD3 BRD9 CAMSAP1 CARS2 CASP8 CCDC50 CCPG1 CCSER2 CDC37 CLTA CUL3 DBI DBN1 DNMT3B DPPA4 EED EPS8 EVA1A FLCN FUNDC1 GORASP2 HYPK IRGQ KBTBD7 KLHL5 KXD1 LUC7L2 MESD MKRN1 MRFAP1 MRTFA MTX1 MYBL2 NCOR1 NEDD4 NEK9 OPTN PCNT PLEKHM1 PRKCZ PRUNE2 RAD1 RAP1GAP RASAL3 RETREG1 RETREG2 RIC1 RIPOR1 RPLP1 SAMM50 SEM1 SEPTIN3 SMARCB1 SNCA SNU13 SNX18 SPAG9 SQSTM1 STK3 STK36 TAF7 TBC1D17 TBC1D25 TBC1D5 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 TPPP TRIM21 TRIM25 TRIM32 TTN UPF2 USP10 VHL WDR90
Entrez ID		11076	81631
HPRD ID		18522	14358
Ensembl ID		ENSG00000171368	ENSG00000140941
Uniprot IDs		O94811 Q4L233	Q658J6 Q9GZQ8
PDB IDs			1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04 6LAN 7ELG 7GA8 7GA9 7GAA 7GAB 7GAC 7GAD 7GAE 7GAF 7GAG 7GAH 7GAI 7GAJ 7GAK 7GAL 7GAM 7GAN 7GAO 7GAP 7GAQ 7GAR 7GAS 7GAU 8Q53 8Q7K 8YV6
Enriched GO Terms of Interacting Partners?		Tau Protein Binding Regulation Of Microtubule-based Process Neuron Projection Organization Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Postsynapse Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Microtubule Binding Microtubule Cytoskeleton Negative Regulation Of Protein Metabolic Process Nuclear Envelope Lumen Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Neuron Apoptotic Process Regulation Of Hydrogen Peroxide Metabolic Process Microtubule Collateral Sprouting Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Microtubule-based Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Tau-protein Kinase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Dynein Complex Binding Inclusion Body Axon Positive Regulation Of Synaptic Transmission Cellular Response To Copper Ion Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Membrane Protein Ectodomain Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Neuron Projection Development Amyloid Fibril Formation Cell Death Microglial Cell Activation Positive Regulation Of Autophagy	Autophagy Autophagy Of Mitochondrion Mitophagy Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Organelle Organization Regulation Of Autophagy Vacuole Organization Organelle Assembly Piecemeal Microautophagy Of The Nucleus Protein-phosphatidylethanolamide Deconjugating Activity Microautophagy Catabolic Process Positive Regulation Of Autophagy Protein Delipidation Aggrephagy Cellular Component Assembly Establishment Of Protein Localization Cytoplasm Substrate Localization To Autophagosome Intracellular Protein Localization Protein Transport Protein Binding Positive Regulation Of Catabolic Process Cytosol Endoplasmic Reticulum-autophagosome Adaptor Activity Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Stability Proteolysis Involved In Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Cellular Component Organization Response To Mitochondrial Depolarisation Proteolysis Regulation Of Organelle Organization Regulation Of Macroautophagy Protein Monoubiquitination GTPase Activator Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Macroautophagy Phagophore Assembly Site Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Cell Projection Assembly
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