TPPP and TUBB

Number of citations of the paper that reports this interaction (PubMedID 27671864)
0

Data Source:
BioGRID (pull down)

		TPPP	TUBB
Description		tubulin polymerization promoting protein	tubulin beta class I
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Perinuclear Region Of Cytoplasm Mitotic Spindle Microtubule Bundle Postsynaptic Golgi Apparatus	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Microtubule Binding Tubulin Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Microtubule Bundle Formation Oligodendrocyte Development Astral Microtubule Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Myelination Positive Regulation Of Protein Polymerization Myelin Assembly Microtubule Polymerization Oligodendrocyte Differentiation Cell Division Microtubule Nucleation By Microtubule Organizing Center Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Tubulin Deacetylation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Esophageal adenocarcinoma ( 27527254) Estimated glomerular filtration rate ( 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Haemorrhoidal disease ( 33888516) Idiopathic downbeat nystagmus ( 32157568) Ulcerative colitis ( 20228799 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: APP CDK11B DYNLL2 GAPDH GSK3B HDAC6 MAP1LC3B ROCK1 SNCA TUBB ZNF114	84 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		11076	203068
HPRD ID		18522	01852
Ensembl ID		ENSG00000171368	ENSG00000196230
Uniprot IDs		O94811 Q4L233	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs			3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6
Enriched GO Terms of Interacting Partners?		Tau Protein Binding Regulation Of Microtubule-based Process Neuron Projection Organization Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Postsynapse Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Microtubule Binding Microtubule Cytoskeleton Negative Regulation Of Protein Metabolic Process Nuclear Envelope Lumen Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Neuron Apoptotic Process Regulation Of Hydrogen Peroxide Metabolic Process Microtubule Collateral Sprouting Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Microtubule-based Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Tau-protein Kinase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Dynein Complex Binding Inclusion Body Axon Positive Regulation Of Synaptic Transmission Cellular Response To Copper Ion Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Membrane Protein Ectodomain Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Neuron Projection Development Amyloid Fibril Formation Cell Death Microglial Cell Activation Positive Regulation Of Autophagy	Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly
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