TPPP and ZNF114

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPPP	ZNF114
Description		tubulin polymerization promoting protein	zinc finger protein 114
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Perinuclear Region Of Cytoplasm Mitotic Spindle Microtubule Bundle Postsynaptic Golgi Apparatus	Nucleus Extracellular Exosome
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Microtubule Binding Tubulin Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Microtubule Bundle Formation Oligodendrocyte Development Astral Microtubule Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Myelination Positive Regulation Of Protein Polymerization Myelin Assembly Microtubule Polymerization Oligodendrocyte Differentiation Cell Division Microtubule Nucleation By Microtubule Organizing Center Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Tubulin Deacetylation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Esophageal adenocarcinoma ( 27527254) Estimated glomerular filtration rate ( 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Haemorrhoidal disease ( 33888516) Idiopathic downbeat nystagmus ( 32157568) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		11 interacting genes: APP CDK11B DYNLL2 GAPDH GSK3B HDAC6 MAP1LC3B ROCK1 SNCA TUBB ZNF114	10 interacting genes: CENATAC CLIP4 KIAA0753 KLHL2 KRTAP10-6 MAP7 MYO15B SUFU TPPP ZNF8
Entrez ID		11076	163071
HPRD ID		18522	14463
Ensembl ID		ENSG00000171368	ENSG00000178150
Uniprot IDs		O94811 Q4L233	Q8NC26
PDB IDs
Enriched GO Terms of Interacting Partners?		Tau Protein Binding Regulation Of Microtubule-based Process Neuron Projection Organization Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Postsynapse Regulation Of Neuron Apoptotic Process Positive Regulation Of Catabolic Process Microtubule Binding Microtubule Cytoskeleton Negative Regulation Of Protein Metabolic Process Nuclear Envelope Lumen Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Neuron Apoptotic Process Regulation Of Hydrogen Peroxide Metabolic Process Microtubule Collateral Sprouting Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Microtubule-based Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Protein-containing Complex Assembly Tau-protein Kinase Activity Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Dynein Complex Binding Inclusion Body Axon Positive Regulation Of Synaptic Transmission Cellular Response To Copper Ion Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Membrane Protein Ectodomain Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Neuron Projection Development Amyloid Fibril Formation Cell Death Microglial Cell Activation Positive Regulation Of Autophagy	Cytoskeleton Microtubule-based Process Postsynaptic Golgi Apparatus Cytoplasmic Microtubule Organization Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Microtubule Organizing Center
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