SREBF2 and RAB11B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SREBF2	RAB11B
Description		sterol regulatory element binding transcription factor 2	RAB11B, member RAS oncogene family
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex	Cytoplasm Endosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion	Receptor Recycling Protein Transport Melanosome Transport Endocytic Recycling Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Monoatomic Anion Transport Constitutive Secretory Pathway Regulated Exocytosis Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance By Transcytosis Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	TBC/RABGAPs RAB geranylgeranylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 27680694 31043758) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	11 interacting genes: APP IKBKG MEOX2 MYO5B OPTN PRKG2 RAB11FIP2 RAB11FIP3 RAB11FIP5 SNCA SREBF2
Entrez ID		6721	9230
HPRD ID		02726	05009
Ensembl ID		ENSG00000198911	ENSG00000185236
Uniprot IDs		Q12772	Q15907
PDB IDs		1UKL	2F9L 2F9M 4OJK
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process	Recycling Endosome Regulation Of Protein Localization Recycling Endosome Membrane Negative Regulation Of Adiponectin Secretion Vesicle-mediated Transport Cytoplasmic Vesicle Membrane Positive Regulation Of Protein Localization Negative Regulation Of Transport Establishment Of Localization In Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Small GTPase Binding Regulated Exocytosis Identical Protein Binding Regulation Of Amyloid-beta Clearance Regulation Of Neurotransmitter Uptake Endosome Regulation Of Autophagy Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Negative Regulation Of Secretion By Cell Regulation Of Receptor Recycling K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Small Molecule Metabolic Process Amyloid Fibril Formation Signal Release Endocytosis Microglial Cell Activation Positive Regulation Of Defense Response Negative Regulation Of Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Exocytosis Regulation Of Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Localization Positive Regulation Of Catabolic Process Protein Localization To Cell Periphery Insulin Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion
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