SREBF2 and ABLIM2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		SREBF2	ABLIM2
Gene Name		sterol regulatory element binding transcription factor 2	actin binding LIM protein family, member 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex	Actin Cytoskeleton Myofibril
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding	Actin Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis	Transcription, DNA-templated Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Axon guidance DCC mediated attractive signaling Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	2 interactors: ABRA SREBF2
Entrez ID		6721	84448
HPRD ID		02726	10623
Ensembl ID		ENSG00000198911	ENSG00000163995
Uniprot IDs		Q12772	Q6H8Q1
PDB IDs		1UKL	1V6G 1WIG 2L3X
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Transport Response To Low-density Lipoprotein Particle Cellular Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Regulation Of Cholesterol Homeostasis Response To Lipoprotein Particle Positive Regulation Of Cholesterol Storage Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Lipid Transport Regulation Of Cholesterol Efflux Protein Import Into Nucleus, Translocation Positive Regulation Of Lipid Storage Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Regulation Of Lipid Storage Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport Transcription, DNA-templated Cholesterol Metabolic Process Protein Import Into Nucleus RNA Biosynthetic Process Nuclear Import Sterol Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Import Protein Localization To Nucleus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Metabolic Process
Tagcloud ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Difference) ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous
Tagcloud (Intersection) ?