SREBF2 and INSIG1

Number of citations: 24 (PubMedID 12242332)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vitro, in vivo)

		SREBF2	INSIG1
Name		sterol regulatory element binding transcription factor 2	insulin induced gene 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex
	Molecular Function	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Regulation of cholesterol biosynthesis by SREBP (SREBF)
GWAS		Alanine aminotransferase levels ( 33547301 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Birth weight ( 27680694 31043758 ) Caffeine consumption from tea ( 33287642 ) General cognitive ability ( 29844566 ) Processed meat consumption ( 32066663 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )	Bladder cancer (smoking interaction) ( 24662972 ) Diverticular disease ( 30177863 ) Energy expenditure (24h) ( 28476931 ) Formal thought disorder in schizophrenia ( 22648509 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 ) Plasma anti-thyroglobulin levels ( 29678681 ) Triiodothyronine levels and thyroxine levels ( 30843173 )
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	11 interacting genes: AQP6 BDKRB1 HMGCR HTR2B PCK1 PSMA7 PSMC3 SCAP SREBF2 TMEM237 VCP
Entrez ID		6721	3638
HPRD ID		02726	03633
Ensembl ID		ENSG00000198911	ENSG00000186480
Uniprot IDs		Q12772	A4D2M9 F5H6P3 O15503
PDB IDs		1UKL	4J81
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process	Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Lipid Biosynthetic Process Proteasome Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Negative Regulation Of Amyloid-beta Clearance Regulation Of Steroid Biosynthetic Process Response To Sterol Depletion Alcohol Metabolic Process Regulation Of Steroid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Regulation Of Amyloid-beta Clearance Endoplasmic Reticulum ER-nucleus Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Steroid Metabolic Process Modification-dependent Protein Catabolic Process Nitrate Transmembrane Transporter Activity Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Serine Kinase Activity (using GTP As Donor) Flavin Adenine Dinucleotide Catabolic Process SREBP-SCAP Complex ER To Golgi Transport Vesicle Membrane Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Bradykinin Receptor Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process C-8 Sterol Isomerase Activity VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Response To Vitamin B3 Regulation Of Protein Catabolic Process Small Molecule Metabolic Process