SREBF2 and KPNB1

Number of citations of the paper that reports this interaction (PMID 10397761)
28

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		SREBF2	KPNB1
Gene Name		sterol regulatory element binding transcription factor 2	karyopherin (importin) beta 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364)
Protein-Protein Interactions		48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP
Entrez ID		6721	3837
HPRD ID		02726	04114
Ensembl ID		ENSG00000198911
Uniprot IDs		Q12772	B7Z752 B7ZAV6 Q14974
PDB IDs		1UKL	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process	Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance
Tagcloud ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Difference) ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Intersection) ?