SREBF2 and SLC4A4

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		SREBF2	SLC4A4
Description		sterol regulatory element binding transcription factor 2	solute carrier family 4 member 4
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex	Cytosol Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Regulation Of Intracellular PH Transmembrane Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases			Proximal renal tubular acidosis (RTA type 2)
GWAS		Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 27680694 31043758) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		6721	8671
HPRD ID		02726	04516
Ensembl ID		ENSG00000198911	ENSG00000080493
Uniprot IDs		Q12772	A5JJ20 Q9Y6R1
PDB IDs		1UKL	6CAA
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process	Carbonate Dehydratase Activity Bicarbonate Transport Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Chemical Homeostasis Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Cellular Response To Fluid Shear Stress Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Regulation Of Cholesterol Metabolic Process Intracellular PH Reduction Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Homeostatic Process Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Steroid Biosynthetic Process Regulation Of Intracellular PH Regulation Of Cellular PH Intracellular Chemical Homeostasis Regulation Of PH Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Cellular Homeostasis Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity C-8 Sterol Isomerase Activity Positive Regulation Of Lipid Metabolic Process Lyase Activity Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Sodium:bicarbonate Symporter Activity Regulation Of Lipid Biosynthetic Process Regulation Of Macroautophagy Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport CAMP-dependent Protein Kinase Activity Basolateral Plasma Membrane Channel Activator Activity Positive Regulation Of Cholesterol Storage Auditory Receptor Cell Development Phagosome Acidification Cellular Response To Nutrient Levels CAMP/PKA Signal Transduction
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