SREBF2 and ARHGEF1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		SREBF2	ARHGEF1
Description		sterol regulatory element binding transcription factor 2	Rho guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 27680694 31043758) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	12 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA RNF10 SREBF2 TCF4
Entrez ID		6721	9138
HPRD ID		02726	03511
Ensembl ID		ENSG00000198911	ENSG00000076928
Uniprot IDs		Q12772	M0QZR4 Q92888
PDB IDs		1UKL	1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process	G Protein Activity Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction GTPase Activity Regulation Of Cell Communication Regulation Of Signaling Membrane Disassembly Nuclear Membrane Disassembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane GTP Binding Intracellular Signaling Cassette Wound Healing, Spreading Of Cells Cellular Response To Gamma Radiation Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Component Biogenesis Cellular Response To Nerve Growth Factor Stimulus Regulation Of Developmental Process Glutamatergic Synapse Response To Nerve Growth Factor Regulation Of Cellular Component Organization Nuclear Membrane Organization Non-canonical Wnt Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation E-box Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Regulation Of Cell Projection Organization Positive Regulation Of MiRNA Metabolic Process Rho Protein Signal Transduction
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