SREBF2 and KLF13

Number of citations of the paper that reports this interaction (PMID 16303770)
5

Data Source:
BioGRID (pull down)

		SREBF2	KLF13
Gene Name		sterol regulatory element binding transcription factor 2	Kruppel-like factor 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex	Nucleus
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis	Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	9 interactors: CREBBP EP300 KAT2B PCBD1 PRPF4B SERPINH1 SIN3A SREBF1 SREBF2
Entrez ID		6721	51621
HPRD ID		02726	05620
Ensembl ID		ENSG00000198911	ENSG00000169926
Uniprot IDs		Q12772	Q9Y2Y9
PDB IDs		1UKL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Gene Expression Rhythmic Process Positive Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Histone Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromatin Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Cellular Response To Heat Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Response To Organic Substance Chromatin Organization Peptidyl-lysine Modification Regulation Of Binding Cellular Response To Stress Regulation Of Protein Deacetylation Regulation Of Transcription, DNA-templated
Tagcloud ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	advantage cardiomyocyte cardiomyocytes cognate congenital continues dissection ease elucidating embryos finger gata4 genetically holds inability manipulating manipulations modifier morphogenesis multidisciplinary owing promise regenerative requirement starting took unlike xenopus
Tagcloud (Difference) ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	advantage cardiomyocyte cardiomyocytes cognate congenital continues dissection ease elucidating embryos finger gata4 genetically holds inability manipulating manipulations modifier morphogenesis multidisciplinary owing promise regenerative requirement starting took unlike xenopus
Tagcloud (Intersection) ?