COPS8 and CUL1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down)

		COPS8	CUL1
Description		COP9 signalosome subunit 8	cullin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Lysosome Organization Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Oxidative Stress TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 UBC USHBP1	62 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CEBPA CENPE CENPW CFLAR CFTR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 DVL2 E2F1 EIF4ENIF1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 FBXW8 GHR GPS1 HIPK2 HOOK1 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		10920	8454
HPRD ID		16737	04389
Ensembl ID		ENSG00000198612	ENSG00000055130
Uniprot IDs		Q99627	A0A090N7U0 B3KTW0 Q13616
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CAF 8CDJ 8CDK 8OR0 8OR2 8OR3 8OR4 8UA6 8UBT 8UBU 8VVY 9JKB 9KBD
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Modification Process Cytosol Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding DeNEDDylase Activity Ubiquitin Ligase Complex Scaffold Activity Protein Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of T Cell Apoptotic Process Eukaryotic Translation Initiation Factor 3 Complex Necroptotic Process Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Programmed Necrotic Cell Death T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Cytoplasm Response To Methotrexate Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of T Cell Apoptotic Process Sulfite Oxidase Activity Negative Regulation Of Helicase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1 To G0 Transition Protein Localization To Astral Microtubule Protein-containing Complex Leukocyte Apoptotic Process Translation Initiation Factor Activity Dihydrofolate Reductase Activity Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification Process Protein Metabolic Process Protein Neddylation Macromolecule Metabolic Process Cytosol Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Nucleus Nucleoplasm Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Deneddylation Macromolecule Catabolic Process NEDD8 Transferase Activity Protein K48-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Polyubiquitination Cytoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intracellular Signal Transduction Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Protein Monoubiquitination Ubiquitin-like Ligase-substrate Adaptor Activity Cullin Family Protein Binding Positive Regulation Of Signal Transduction Protein Destabilization Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process
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