COPS8 and COPS7A

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		COPS8	COPS7A
Gene Name		COP9 signalosome subunit 8	COP9 signalosome subunit 7A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm COP9 Signalosome
	Molecular Function
	Biological Process	Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Proliferation Cullin Deneddylation	Cullin Deneddylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 JUN MAPRE1 NFKBIA TP53 USHBP1	21 interactors: COPS2 COPS3 COPS4 COPS5 COPS8 CSNK2A1 CSNK2B CUL1 CUL5 EIF3E GPS1 JUN NFE2L2 PMF1 PPBP PRKD1 PSMD4 PTGS2 RAF1 TOM1L1 TP53
Entrez ID		10920	50813
HPRD ID		16737	16736
Ensembl ID			ENSG00000111652
Uniprot IDs		Q99627	Q567U8 Q9UBW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Viral Process Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Protein Import Into Nucleus Apoptotic Signaling Pathway Nuclear Import Cell Proliferation Cell Cycle Arrest Protein Metabolic Process Protein Import Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Cellular Macromolecule Catabolic Process Protein Localization To Nucleus Response To Radiation Circadian Rhythm Interaction With Symbiont Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Localization To Organelle Modification-dependent Protein Catabolic Process Apoptotic Process Protein Monoubiquitination Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Death Negative Regulation Of DNA Binding Death Signal Transduction Toll-like Receptor 5 Signaling Pathway Protein Catabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of Binding Mitotic Cell Cycle Phase Transition Nucleocytoplasmic Transport Cell Cycle Phase Transition Nuclear Transport Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To UV Cellular Response To Potassium Ion Starvation Positive Regulation Of Neuron Apoptotic Process Toll-like Receptor 2 Signaling Pathway	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Regulation Of Cell Proliferation Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Modification Process Cellular Metabolic Process Signaling Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Cell Communication Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Cell Cycle Apoptotic Signaling Pathway Protein Catabolic Process Regulation Of Cellular Process Intracellular Signal Transduction Negative Regulation Of Cell Death Response To Stimulus Mitotic Cell Cycle Process
Tagcloud ?			abomasum actb b2m blat butterfat calculating coro1b cows dnajc19 eif3k emd gapdh genorm golga5 goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification
Tagcloud (Difference) ?			abomasum actb b2m blat butterfat calculating coro1b cows dnajc19 eif3k emd gapdh genorm golga5 goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification
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