COPS8 and SUOX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS8	SUOX
Description		COP9 signalosome subunit 8	sulfite oxidase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Protein Binding	Protein Binding Sulfite Oxidase Activity Oxidoreductase Activity Heme Binding Molybdenum Ion Binding Molybdopterin Cofactor Binding Metal Ion Binding
	Biological Process	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Protein Neddylation Regulation Of Protein Neddylation	Sulfur Compound Metabolic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Sulfide oxidation to sulfate
Drugs			{[2-Amino-4-oxo-6,7-di(sulfanyl-κS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Anorexia nervosa ( 28494655) Asthma ( 32296059 31959851 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 31527586) Intelligence (MTAG) ( 29326435) Medication use (glucocorticoids) ( 31015401) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 22885925) Refractive error ( 32231278) Type 1 diabetes ( 31152121 18198356) Vitiligo ( 22951725)
Interacting Genes		17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 UBC USHBP1	77 interacting genes: ACOT11 BAG4 C1D CAMK2A CDCA4 CEP76 COA7 COPS8 CRX CTAG1A CTAG1B CYB5R2 DMAP1 DNAAF19 DUSP21 EIF3F ERICH4 EYA2 FAM217B FMNL2 FMR1 FNDC3B GOLGA6L9 HADHB HMG20A INCA1 ING5 ISCA2 ITGB3BP KIAA0753 KRT26 KRT27 KRT34 KRT40 LMO4 MAGEA11 MAGEB10 MBD3L1 MDFI MED28 MEIS3 MORN3 MYL7 MYO1B NUP62 PEX19 PIH1D2 POMC PRRX1 PTTG2 REL RELA RHOH RIMOC1 RINT1 RPLP1 RSKR RUSC1 SERTAD3 SGTA SH3BP5L SNF8 SOHLH1 SPC24 STAT5B STH SYNGAP1 TEX12 TRIB3 TSC1 UBQLN2 UBR2 VBP1 VPS28 ZNF143 ZNF576 ZXDC
Entrez ID		10920	6821
HPRD ID		16737	06055
Ensembl ID		ENSG00000198612	ENSG00000139531
Uniprot IDs		Q99627	P51687
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	1MJ4
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Modification Process Cytosol Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding DeNEDDylase Activity Ubiquitin Ligase Complex Scaffold Activity Protein Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of T Cell Apoptotic Process Eukaryotic Translation Initiation Factor 3 Complex Necroptotic Process Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Programmed Necrotic Cell Death T Cell Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Lymphocyte Apoptotic Process Cytoplasm Response To Methotrexate Inositol-3,4,5,6-tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-3,4,6-trisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of T Cell Apoptotic Process Sulfite Oxidase Activity Negative Regulation Of Helicase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1 To G0 Transition Protein Localization To Astral Microtubule Protein-containing Complex Leukocyte Apoptotic Process Translation Initiation Factor Activity Dihydrofolate Reductase Activity Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Inositol-1,3,4,5-tetrakisphosphate 6-kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway	Protein Binding Structural Constituent Of Skin Epidermis Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Cytosol Positive Regulation Of Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Nucleobase-containing Compound Metabolic Process NF-kappaB Complex Regulation Of DNA-templated Transcription Cytoplasm Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Protein Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?