COPS8 and COPS4

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vitro, in vivo)

		COPS8	COPS4
Gene Name		COP9 signalosome subunit 8	COP9 signalosome subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Synaptic Vesicle COP9 Signalosome Cell Junction Extracellular Vesicular Exosome
	Molecular Function		Protein Binding
	Biological Process	Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Proliferation Cullin Deneddylation	Protein Deneddylation Cullin Deneddylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 JUN MAPRE1 NFKBIA TP53 USHBP1	17 interactors: C19orf57 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 FOS IKBKB JUN MBIP RCBTB2 TP53 USHBP1 YWHAQ
Entrez ID		10920	51138
HPRD ID		16737	09888
Ensembl ID			ENSG00000138663
Uniprot IDs		Q99627	B3KM48 Q9BT78
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Viral Process Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Protein Import Into Nucleus Apoptotic Signaling Pathway Nuclear Import Cell Proliferation Cell Cycle Arrest Protein Metabolic Process Protein Import Protein Import Into Nucleus, Translocation Release Of Cytochrome C From Mitochondria Cellular Macromolecule Catabolic Process Protein Localization To Nucleus Response To Radiation Circadian Rhythm Interaction With Symbiont Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Localization To Organelle Modification-dependent Protein Catabolic Process Apoptotic Process Protein Monoubiquitination Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Death Negative Regulation Of DNA Binding Death Signal Transduction Toll-like Receptor 5 Signaling Pathway Protein Catabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of Binding Mitotic Cell Cycle Phase Transition Nucleocytoplasmic Transport Cell Cycle Phase Transition Nuclear Transport Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To UV Cellular Response To Potassium Ion Starvation Positive Regulation Of Neuron Apoptotic Process Toll-like Receptor 2 Signaling Pathway	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Signal Transduction Response To Radiation Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Cellular Response To Extracellular Stimulus Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Calcium Ion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Innate Immune Response Response To Growth Factor Negative Regulation Of Nucleic Acid-templated Transcription SMAD Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization
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