EHMT2 and H3C14

Number of citations of the paper that reports this interaction (PubMedID 22387026)
42

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study)

		EHMT2	H3C14
Description		euchromatic histone lysine methyltransferase 2	H3 clustered histone 14
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body Nuclear Speck	Chromatin Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3K56 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Promoter-specific Chromatin Binding	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Synaptonemal Complex Assembly Spermatid Development Cellular Response To Starvation Fertilization Peptidyl-lysine Dimethylation Methylation Organ Growth Phenotypic Switching Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Behavioral Response To Cocaine Oocyte Development Neuron Fate Specification Cellular Response To Cocaine Negative Regulation Of Autophagosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Gene Expression
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 23760081 25802187) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		63 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EIF4ENIF1 EPDR1 ESR1 ESS2 EXOSC7 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MAZ MX2 NAA10 NAA11 NAPRT PLOD3 PRPF6 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 UBASH3A VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837	66 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CBX2 CBX4 CBX6 CBX7 CBX8 CDCA8 CDK8 CHUK DDB2 DNAJC9 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1
Entrez ID		10919	126961
HPRD ID		06854	11822
Ensembl ID		ENSG00000204371	ENSG00000203811
Uniprot IDs		A0A024RCN9 A2ABF8 A2ABF9 B7Z852 Q59FM7 Q96KQ7	Q71DI3
PDB IDs		2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1 7BTV 7BUC 7DCF 7T7L 7X73 7XUA 7XUB 7XUC 7XUD 8VV8 8Z7C 8Z7D 8Z7E	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA 7JZV 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7TAN 7U50 7U51 7U52 7U53 7UV9 7UVA 7XCR 7XCT 7XD0 7YRD 8AAG 8ATF 8AV6 8GRQ 8HQY 8HR1 8JLB 8JLD 8OL1 8VMJ 8VMN 8VO0 8VOB 8VWS 8VWT 8VWU 8VWV 8X7I 8X7J 8X7K 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9GMK 9GMR 9IPU
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of RNA Biosynthetic Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Zinc Ion Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein-DNA Complex Assembly Nucleosome Organization Protein Binding Euchromatin Metal Ion Binding Negative Regulation Of Transcription By RNA Polymerase II Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein N-terminal-serine Acetyltransferase Activity Chromosome Organization NatA Complex Chromatin Protein-N-terminal Amino-acid Acetyltransferase Activity Chromosome Protein Heterodimerization Activity Cellular Component Assembly RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleosomal DNA Binding Establishment Of Protein Localization To Chromatin Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding	Chromatin Organization Chromatin Remodeling Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Chromosome Positive Regulation Of Biosynthetic Process Histone Binding Histone Methyltransferase Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Histone H3K4 Monomethyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Transcription Coactivator Activity Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Histone H3 Methyltransferase Activity Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Metaphase Plate Congression Histone H3K4 Methyltransferase Activity Methylation Methyltransferase Activity Acetyltransferase Activity
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