EHMT2 and THAP7

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EHMT2	THAP7
Description		euchromatic histone lysine methyltransferase 2	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body Nuclear Speck	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3K56 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Promoter-specific Chromatin Binding	Transcription Corepressor Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Histone H4 Reader Activity General Transcription Initiation Factor Binding Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Replication Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Synaptonemal Complex Assembly Spermatid Development Cellular Response To Starvation Fertilization Peptidyl-lysine Dimethylation Methylation Organ Growth Phenotypic Switching Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Behavioral Response To Cocaine Oocyte Development Neuron Fate Specification Cellular Response To Cocaine Negative Regulation Of Autophagosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 23760081 25802187) Chronotype ( 30696823) Clostridioides difficle infection ( 33841421) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Takayasu arteritis ( 25604533) Type 2 diabetes ( 29358691) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		63 interacting genes: ABHD17A ANKRD28 ATF7IP AURKA CACNA1A CCDC33 CHCHD2 CSNK2A1 CUX1 DNMT3A E4F1 EIF4A3 EIF4ENIF1 EPDR1 ESR1 ESS2 EXOSC7 FAM161A H1-1 H1-5 H3-3B H3-4 H3C1 H3C14 H3C15 HGS HIC2 ITGB5 KLF12 KLF6 LASP1 LIG1 LIMS1 LMO2 LNX1 MAZ MX2 NAA10 NAA11 NAPRT PLOD3 PRPF6 PRRC2B PSMA1 PTGER4 RD3 RELB RERE RPA1 RUVBL2 THAP7 TP53 UBASH3A VEZF1 WIZ XAGE2 ZBTB38 ZNF446 ZNF512B ZNF688 ZNF775 ZNF785 ZNF837	63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1
Entrez ID		10919	80764
HPRD ID		06854	15500
Ensembl ID		ENSG00000204371	ENSG00000184436
Uniprot IDs		A0A024RCN9 A2ABF8 A2ABF9 B7Z852 Q59FM7 Q96KQ7	Q9BT49
PDB IDs		2O8J 3DM1 3K5K 3RJW 4NVQ 5JHN 5JIN 5JIY 5JJ0 5T0K 5T0M 5TTF 5TUY 5V9I 5VSC 5VSE 6MM1 7BTV 7BUC 7DCF 7T7L 7X73 7XUA 7XUB 7XUC 7XUD 8VV8 8Z7C 8Z7D 8Z7E
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Structural Constituent Of Chromatin Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of RNA Biosynthetic Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleosome Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Zinc Ion Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein-DNA Complex Assembly Nucleosome Organization Protein Binding Euchromatin Metal Ion Binding Negative Regulation Of Transcription By RNA Polymerase II Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein N-terminal-serine Acetyltransferase Activity Chromosome Organization NatA Complex Chromatin Protein-N-terminal Amino-acid Acetyltransferase Activity Chromosome Protein Heterodimerization Activity Cellular Component Assembly RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleosomal DNA Binding Establishment Of Protein Localization To Chromatin Positive Regulation Of Biosynthetic Process TFIID-class Transcription Factor Complex Binding	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Thioesterase Binding Protein Binding Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Toll Signaling Pathway Cytosol Intermediate Filament Organization Protein-containing Complex Disassembly Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Wnt Signaling Pathway Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Protein Serine/threonine Phosphatase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Nitrogen Starvation Cytoskeleton CD40 Receptor Complex
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